Synthesis of highly tritium labeled steroids for evaluation of aromatase and steroidsulfatase activities in endometrial tumors

N V Bochkareva; I V Kondakova; L A Kolomiets; A B Muntyan; V P Shevchenko; I Yu Nagaev; K V Shevchenko; N F Myasoedov; N N Dorofeeva

doi:10.1007/s10517-006-0397-4

Synthesis of highly tritium labeled steroids for evaluation of aromatase and steroidsulfatase activities in endometrial tumors

Bull Exp Biol Med. 2006 Oct;142(4):478-80. doi: 10.1007/s10517-006-0397-4.

[Article in English, Russian]

Authors

N V Bochkareva¹, I V Kondakova, L A Kolomiets, A B Muntyan, V P Shevchenko, I Yu Nagaev, K V Shevchenko, N F Myasoedov, N N Dorofeeva

Affiliation

¹ Institute of Oncology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences. biochem@oncology.tomsk.ru

PMID: 17415442
DOI: 10.1007/s10517-006-0397-4

Abstract

Data on activities of estrogen-synthesis enzymes (aromatase and steroidsulfatase) in endometrial tumors were obtained by sensitive and highly precise radioisotope methods. The results clear out some pathogenetic aspects in the development and progress of malignant tumors in the endometrium.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aromatase / metabolism*
Cell Differentiation
Endometrial Neoplasms / enzymology*
Endometrial Neoplasms / pathology*
Estrone / analogs & derivatives
Estrone / metabolism
Female
Humans
Isotope Labeling / methods
Menopause
Middle Aged
Neoplasm Staging
Postmenopause
Steryl-Sulfatase / metabolism*
Tritium

Substances

Tritium
Estrone
Aromatase
Steryl-Sulfatase
estrone sulfate