Abstract
Thirty-two young women who desired sexual reassignment were treated with large doses of androgen for a period of 1 year or more, followed by total hysterectomy. Histological examination revealed marked atrophy of cervical epithelium which could mimic dysplasia, and variable degrees of endometrial atrophy. The ovaries showed occasional corpora lutea indicating that even in the face of long term androgen therapy, ovulation may occur.
MeSH terms
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Adult
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Androgens / therapeutic use*
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Atrophy
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Carcinoma, Squamous Cell / pathology
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Cervix Uteri / drug effects
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Cervix Uteri / pathology
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Endometrium / drug effects
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Endometrium / pathology
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Female
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Genitalia, Female / drug effects
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Genitalia, Female / pathology*
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Humans
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Middle Aged
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Mucous Membrane / drug effects
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Mucous Membrane / pathology
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Ovary / drug effects
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Ovary / pathology
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Staining and Labeling
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Transsexualism / pathology*
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Uterine Cervical Neoplasms / pathology