Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole

John R Lurain

doi:10.1016/j.ajog.2010.06.073

Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole

Am J Obstet Gynecol. 2010 Dec;203(6):531-9. doi: 10.1016/j.ajog.2010.06.073. Epub 2010 Aug 21.

Author

John R Lurain¹

Affiliation

¹ John I. Brewer Trophoblastic Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. jlurain@nmff.org

PMID: 20728069
DOI: 10.1016/j.ajog.2010.06.073

Abstract

Gestational trophoblastic disease includes hydatidiform mole (complete and partial) and gestational trophoblastic neoplasia (invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor). The epidemiology, pathology, clinical presentation, and diagnosis of each of these trophoblastic disease variants are discussed. Particular emphasis is given to management of hydatidiform mole, including evacuation, twin mole/normal fetus pregnancy, prophylactic chemotherapy, and follow-up.

Publication types

Review

MeSH terms

Abortion, Therapeutic / methods
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Choriocarcinoma / diagnosis
Choriocarcinoma / drug therapy
Choriocarcinoma / mortality
Choriocarcinoma / pathology
Combined Modality Therapy
Female
Follow-Up Studies
Gestational Trophoblastic Disease / diagnosis
Gestational Trophoblastic Disease / drug therapy*
Gestational Trophoblastic Disease / mortality
Gestational Trophoblastic Disease / pathology*
Humans
Hydatidiform Mole / drug therapy
Hydatidiform Mole / pathology
Hysterectomy / methods
Pregnancy
Risk Assessment
Survival Rate
Treatment Outcome
Uterine Neoplasms / diagnosis
Uterine Neoplasms / mortality
Uterine Neoplasms / pathology*
Uterine Neoplasms / therapy