Elsevier

Annals of Oncology

Volume 22, Issue 1, January 2011, Pages 59-67
Annals of Oncology

original articles
gynecologic tumors
Outcomes after radical hysterectomy according to tumor size divided by 2-cm interval in patients with early cervical cancer

https://doi.org/10.1093/annonc/mdq321Get rights and content
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Abstract

Background: This study investigated the outcomes after radical hysterectomy according to tumor size divided by 2-cm interval in patients with International Federation of Obstetrics and Gynecology stage IA2–IIA cervical cancer.

Patients and methods: A total of 1415 patients were eligible for participation in the study and were retrospectively analyzed. Patients were divided into four groups according to tumor size (i.e. ≤2, 2–4, 4–6 and >6 cm). The relationships between tumor size and other clinicopathologic risk factors, the probability of adjuvant therapy, survival parameters, recurrence-free survival (RFS) and overall survival (OS) were analyzed.

Results: The incidence of intermediate- and high-risk factors gradually increased with increasing tumor size. Adjuvant therapy was required in 13.6%, 34.0%, 56.7% and 92.9% of patients with tumor sizes of ≤2, 2–4, 4–6 and >6 cm, respectively (P < 0.001). The risks of recurrence and death gradually increased with increasing tumor size, after adjusting for other significant prognostic factors in multivariate analysis (P < 0.001 and < 0.001, respectively). Even in patients with no intermediate- or high-risk factors, tumor size was a significant predictor of RFS and OS (P < 0.001 and < 0.001, respectively). Immediate surgical parameters did not significantly differ according to tumor size.

Conclusions: Tumor size divided by a 2-cm interval was an independent prognostic factor and correlated well with other risk factors and with the need for adjuvant therapy.

Keywords

early cervical cancer
radical hysterectomy
risk factor
surgical outcome
survival outcome
tumor size

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