Cancer Cell
Volume 22, Issue 1, 10 July 2012, Pages 106-116
ArticleA Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2
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Graphical Abstract
Highlights
► Ubiquitylated FANCD2 and BRCA1 are required to protect stalled forks from degradation ► Fork degradation in FA-deficient cells is prevented by chemical inhibition of MRE11 ► FANCD2 deficiency is rescued by elevated RAD51 levels or stabilized RAD51 filaments ► FANCD2 is epistatic with RAD51/BRCA2 in fork protection, identifying a pathway
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