Original articleGeneral thoracicGynecologic Cancers: Factors Affecting Survival After Pulmonary Metastasectomy
Section snippets
Material and Methods
All patients, who underwent pulmonary resection for metastatic gynecologic cancers between January 1985 and June 2001 at the Mayo Clinic in Rochester, Minnesota, were reviewed. There were a total of 103 patients. Eighteen of these patients also had metastases to other locations, and 15 had pulmonary excision for diagnostic purposes only. These 33 patients were excluded from further analysis. The medical records of the remaining 70 patients were analyzed for patient demographics, location of
Results
The median age of the 70 patients was 59.4 years (range, 31 to 80 years). The primary tumor originated in the uterine corpus in 37 patients (52.9%), endometrium in 23 (32.9%), cervix in 7 (10.0%), ovaries in 2 (2.8%), and vagina in 1 (1.4%). Histopathology was leiomyosarcoma in 29 patients (41.4%), adenocarcinoma in 23 (32.9%), other sarcoma in 11 (15.8%), squamous cell carcinoma in 5 (7.1%), and choriocarcinoma and endolymphatic stromal myosis in 1 each (1.4%). The initial gynecologic
Comment
Approximately 80,000 women in 2006 in the United States will develop gynecologic cancers, 36% of whom will eventually die from their disease [16]. Lung metastases are present in approximately 30% of these patients, and the lung is the only site of metastases in 20% [12]. Although pulmonary metastases from gynecologic cancers are not uncommon and occur in 2% to 28% of patients, little information is available regarding the efficacy of pulmonary metastasectomy.
Torek [17] in 1930 is believed to be
References (30)
- et al.
Adenocarcinoma of the kidney with metastasis to the lung
J Urol
(1939) - et al.
Long-term results after pulmonary resection of renal cell carcinoma metastases
Ann Thorac Surg
(2002) - et al.
Pulmonary resection of metastatic renal cell carcinoma
Ann Thorac Surg
(1994) - et al.
Surgical treatment of hepatic and pulmonary metastases from colon cancer
Ann Thorac Surg
(2001) - et al.
Colorectal lung metastasesresults of surgical excision
Ann Thorac Surg
(1992) - et al.
Surgical resection of lung metastases from epithelial tumors
Ann Thorac Surg
(2004) - et al.
Surgery for pulmonary metastasesa 20-year experience
Ann Thorac Surg
(1984) - et al.
Can we predict long-term survival after pulmonary metastasectomy for renal cell carcinoma?
Ann Thorac Surg
(2005) - et al.
Long term results of lung metastasectomyprognostic analysis based on 5206 cases
J Thorac Cardiovasc Surg
(1997) - et al.
Diagnosis and treatment of pulmonary metastases from cervical carcinoma
Gynecol Oncol
(1990)
Pulmonary resection for metastases from gynecological cancersMGH experience
Gynecol Oncol
Pulmonary metastasis from carcinoma of the uterine cervix
Gynecol Oncol
Resection of pulmonary metastases from uterine sarcomas
Gynecol Oncol
Surgical treatment of pulmonary metastases from uterine cervical cancer. Operation method by lung tumor size
J Thorac Cardiovasc Surg
Pulmonary metastasectomy for uterine cervical cancera multivariate analysis
Ann Thorac Surg
Cited by (65)
Incidence, prognostic factors, and a nomogram of cervical cancer with lung metastasis: A SEER-based study
2024, Journal of Gynecology Obstetrics and Human ReproductionTherapeutic approaches in patients with bone metastasis due to endometrial carcinoma – A systematic review
2023, Journal of Bone OncologyLung Metastases
2019, Abeloff’s Clinical OncologyUterine sarcoma Part I—Uterine leiomyosarcoma: The Topic Advisory Group systematic review
2016, Taiwanese Journal of Obstetrics and GynecologyCitation Excerpt :This is best achieved by resecting the tumor en bloc with adherent structures, even if not overtly infiltrated [33], because patients with no residual disease after surgical resection have an improved survival rate compared with those who undergo a suboptimal surgical resection [33]. Pulmonary metastasectomy, preferring wedge resection, showed a relatively promising result with 5- and 10-year survival rates of 46.8% and 34.3%, respectively, although the overall 3-year disease-free survival rate was only 27.8% [34], which is very similar to the management of pulmonary metastases from ECs [35]. The role of adjuvant radiation therapy (RT) for patients with uLMS is highly controversial and it is often not generally indicated after complete resection of Stage I/II uLMS because the European Organization for Research and Treatment of Cancer trial 55,874 (a randomized study, level of evidence II) failed to show any benefit of postoperative adjuvant RT (50.4 Gy) to treat Stage I and Stage II uLMS [35].
Challenges in the management of recurrent endometrial cancer
2016, Journal of the Chinese Medical Association