ResearchOncologySmall cell carcinoma of the cervix: treatment and survival outcomes of 188 patients
Section snippets
Materials and Methods
Fifty-two patients with neuroendocrine small cell cervical carcinoma who received diagnoses from 1979-2005 were identified from tumor registry databases at 4 hospitals (University of California-San Francisco, Stanford University, University of California-Irvine Medical Center, and Long Beach Memorial Medical Center). After institutional review board approval from these institutions, data were collected from hospital charts, office records, and tumor registry files. The remaining 136 patients
Results
Of 188 patients, 135 had stage I-IIA, 45 had IIB-IVA, and 8 had stage IVB disease.8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46 The median age was 42 years (range, 20–87 years). Demographic characteristics of the patients are shown in Table 1. Vaginal bleeding at presentation was noted in 21.8% of patients and 8% had pain and pressure. Of 115 patients with tumor size documented, 80.0% had
Comment
Small cell cervical carcinoma is rare and is associated with a poor prognosis.47 The Gynecologic Oncology Group attempted to study small cell cervical carcinoma in protocol 66 between 1982 and 1986, but failed to recruit sufficient numbers of patients. As a result, treatment decisions have been based on these small single institution studies, and have extrapolated treatment approaches from the management of small cell cancer of the lung. With 188 patients in this report, to our knowledge, this
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Cite this article as: Cohen JG, Kapp DS, Shin JY, et al. Small cell carcinoma of the cervix: treatment and survival outcomes of 188 patients. Am J Obstet Gynecol 2010;203:347.e1-6.
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