CA-125; a new marker for diagnosis and follow-up of patients with tuberculous peritonitis

doi:10.1016/S1590-8658(00)80841-5

Digestive and Liver Disease

Volume 32, Issue 7, October 2000, Pages 595-597

https://doi.org/10.1016/S1590-8658(00)80841-5 Get rights and content

Abstract

Background. Most malignancies with peritoneal infiltration, especially ovarian cancers and chronic liver diseases associated with ascites give rise to high serum CA-125 levels. Tuberculous peritonitis is another cause for high serum CA-125 levels.

Aim. To investigate the relation between serum CA-125 level and response to treatment in tuberculous peritonitis patients.

Patients. Ten patients with tuberculous peritonitis were enrolled in the study.

Method. Definite diagnosis of tuberculous peritonitis was made by acid-fast smears, specific culture, and polymerase chain reaction. Serum CA-125 levels were measured before and at the fourth month of treatment.

Results. Before antituberculous treatment, serum CA-125 levels of all patients were very high (mean±SD: 475. 80± 106.19 U/ml) and comparable with those of patients with ovarian cancers. At the end of the fourth month of treatment, serum CA-125 levels in all patients decreased to within normal limits (<35 U/ml][20. 80:±5. 18 U/ml) in parallel with the clinical improvement. The differences in CA 125 levels before and after treatment were statistically significant (p<O.001).

Conclusions. Results of our study suggest that serum CA-125 levels in patients with tuberculous peritonitis are as high as ovarian cancers associated with peritoneal infiltration. By the end of the fourth month of antituberculous therapy, serum CA-125 levels have returned to normal. We, therefore, suggest that serum CA-125 can be used to evaluate the efficacy of therapy in tuberculous peritonitis.

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CA-125; a new marker for diagnosis and follow-up of patients with tuberculous peritonitis

Abstract

Clinical features of abdominal tuberculosis

J Infect Dis

Tuberculosis of gastrointestinal tract and peritoneum

Am J Gastroenterol

Tuberculous enteritis and peritonitis. Report of 36 general hospital cases

Arch Intern Med

Diagnosis and management of mycobacterial infection and disease in persons with human immunodeficiency virus infection

Centers for Disease Control, US Department of Health and Human Services. Ann Intern Med

Peritoneal tuberculosis: Laparoscopic patterns and its diagnostic accuracy

Am J Gastroenterol

Tuberculous peritonitis: A study comparing cirrhotic and noncirrhotic patients

J Clin Gastroenterol

Pelvic-peritoneal tuberculosis with elevated serum and peritoneal fluid CA-125 levels: a report of two cases

Gynecol Obstet Invest

Symptoms and investigative findings in 145 patients with tuberculous peritonitis diagnosed by peritoneoscopy and biopsy over a five year period

Gut