Clinical StudiesSystemic Capillary Leak Syndrome: Report on 13 Patients With Special Focus on Course and Treatment☆
Section snippets
Design
The present series is based on a retrospective, cooperative survey of patient files from French departments of Internal Medicine, Nephrology, and Intensive Care Medicine. The patients were admitted over a 20-year period (from 1975 to 1995). Diagnosis of SCLS was made according to the following criteria: history of hypotensive shock with presence of a monoclonal component in the serum and transient hypoprotidemia or hypoalbuminemia with elevated hematocrit during a shock. Three cases have been
Patient 1
In November 1991, a white 49-year-old woman was admitted to an intensive care unit due to a shock following a flu-like illness of 2 days duration. On examination her systolic blood pressure was unmeasurable. In December 1993, she had another attack requiring resuscitation with intravenous fluid. Each episode began with the patient feeling anxious and irritable. Shocks were characterized by elevated hematocrit and decreased albumin serum level. Normal blood pressure was restored by intravenous
Discussion
We report a series of 13 patients with SCLS. The findings obtained in this series confirm and extend those previously reported in literature. First, SCLS appears to be a much more frequent disease than previously thought. Indeed since the first publication by Clarkson, only 34 cases have been published in the literature.[2]Our series adds 10 new cases, indicating that the real prevalence of the disease might have been underestimated. Most of these new cases occurred during the last 5 years;
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This work was supported by Société Nationale Française de Médecine Interne, Société Française de Néphrologie, and Société Française de Réanimation.