International Journal of Radiation Oncology*Biology*Physics
Special featureHigh-dose-rate versus low-dose-rate intracavitary brachytherapy for carcinoma of the cervix☆
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Cited by (112)
Prospective comparison of rectal dose reduction during intracavitary brachytherapy for cervical cancer using three rectal retraction techniques
2016, BrachytherapyCitation Excerpt :Radiation is delivered by two techniques: (1) external beam radiation (EBRT) and (2) intracavitary brachytherapy, typically using a high-dose-rate (HDR) technique, which delivers large radiation doses to the tumor, however, risks late toxicities due to potential dose to organs at risk (OARs). Moderate-to-severe late complications from HDR brachytherapy have been reported to range from 5% to 30% (1–8). A common site for radiation side effects after HDR brachytherapy for cervix cancer is the anterior rectal wall, which may cause rectal bleeding, fibrosis, chronic rectal ulcers, and fistula formation (4, 6).
Afterloading: The technique that rescued brachytherapy
2015, International Journal of Radiation Oncology Biology PhysicsVariable impact of intracavitary brachytherapy fractionation schedule onbiologically effective dose to organs at risk in patients with cervicalcancer
2014, BrachytherapyCitation Excerpt :In contrast, some physicians continue to use LDR or PDR brachytherapy, believing that these approaches have biologic advantages over HDR techniques (13). However, despite the theoretical benefits of LDR or PDR technique in minimizing toxicity to organs at risk, data suggest similar efficacy and toxicity of LDR brachytherapy, PDR brachytherapy, and HDR brachytherapy delivered in various fractionation schedules (6, 14–22). In theory, the benefit of a particular fractionation schedule to individual patients or to small subsets of patients with high-risk features might not be apparent when descriptive statistics are used.
American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part II: High-dose-rate brachytherapy
2012, BrachytherapyCitation Excerpt :Brachytherapy is an important component in the curative management of carcinoma of the cervix, and significantly improves survival (1, 2). High-dose-rate (HDR) and low-dose-rate (LDR) brachytherapy seem to be relatively equivalent treatments in terms of survival outcomes based on existing retrospective and prospective studies (3–11). Advantages of HDR brachytherapy include opportunities for outpatient treatment, avoidance of exposure to staff from the radiation source, consistent and reproducible applicator positioning, and dose optimization attained with a variable dwell-time stepping source (3).
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Presented at the 30th annual meeting of the American Society of Therapeutic Radiology and Oncology, 9–14 October 1988, New Orleans, LA.