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Outcomes in 24 selected patients with stage IVB cervical cancer and excellent performance status treated with radiotherapy and chemotherapy

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Abstract

Purpose

We sought to review outcomes in patients with stage IVB carcinoma of the cervix treated with irradiation in combination with chemotherapy.

Materials and methods

We report outcomes of 24 consecutive patients with good performance status treated from 1998 to 2005. Most of these patients underwent concurrent irradiation with platinum-based chemotherapy. Some patients received subsequent systemic chemotherapy.

Results

All patients underwent external beam radiotherapy; 7 patients (29%) had additional high-dose-rate and 12 (50%) low-dose-rate brachytherapy. Two patients (8%) received an IMRT boost instead of brachytherapy. The mean dose to point A was variable (73.9 ± 19.2 Gy). Twenty patients (83%) received radio-sensitizing platinum-based chemotherapy, and the remaining had radiotherapy alone. Seven patients (29%) had further combination chemotherapy. Therapy was well tolerated. The overall survival was 44% at 36 months and 22% at 5 years.

Conclusion

Patients with stage IVB cervical cancer have mostly been treated with palliative intent. With the advent of concurrent chemoradiation, we have treated many of these cases with aggressive combination therapy. In this series, the use of radiotherapy and multiagent chemotherapy in patients with stage IVB cervical carcinoma and good performance status was well tolerated and resulted in higher survival rates than previously reported.

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Author notes

  1. Israel Zighelboim

    Present address: Barnes-Jewish Hospital Plaza, Maternity Building, 3rd Floor, St. Louis, MO, 63110, USA

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine and Alvin J. Siteman Cancer Center, St. Louis, MO, USA

    Israel Zighelboim, Nicholas P. Taylor, Matthew A. Powell, Randall K. Gibb, Janet S. Rader & David G. Mutch

  2. Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine and Alvin J. Siteman Cancer Center, St. Louis, MO, USA

    Perry W. Grigsby

Authors
  1. Israel Zighelboim
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  2. Nicholas P. Taylor
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  3. Matthew A. Powell
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  4. Randall K. Gibb
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  5. Janet S. Rader
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  6. David G. Mutch
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  7. Perry W. Grigsby
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Corresponding author

Correspondence to Israel Zighelboim.

Additional information

This study was presented at the 37th annual meeting of the Society of Gynecologic Oncologists, Palm Springs, CA, March 2006

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Zighelboim, I., Taylor, N., Powell, M. et al. Outcomes in 24 selected patients with stage IVB cervical cancer and excellent performance status treated with radiotherapy and chemotherapy. Radiat Med 24, 625–630 (2006). https://doi.org/10.1007/s11604-006-0082-6

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  • DOI: https://doi.org/10.1007/s11604-006-0082-6

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