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Clonality analysis suggests that STK11 gene mutations are involved in progression of lobular endocervical glandular hyperplasia (LEGH) to minimal deviation adenocarcinoma (MDA)

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Abstract

Lobular endocervical glandular hyperplasia (LEGH) is a benign proliferative disease of cervical glands. Although histological resemblance of minimal deviation adenocarcinoma (MDA) to LEGH and frequent association of LEGH with MDA have been reported, it still remains unclear whether LEGH is a precancerous lesion of MDA. The present study was undertaken to examine the pathogenetic relationship between LEGH and MDA using a clonality analysis and mutational analyses of the STK11 gene, of which mutations have been reported in MDA. Of nine cases of LEGH only, four were polyclonal and five were monoclonal in composition. Of six LEGH lesions associated with MDA or adenocarcinoma, two were polyclonal and four were monoclonal. In cases of MDA or adenocarcinoma coexisting with LEGH, the patterns of X chromosome inactivation in malignant lesions were identical to those in coexisting LEGH lesions. A mutation of STK11 was only identified in one MDA, but not in LEGH. These results indicate that a subset of LEGH may be a precursor to malignant tumors including MDA and that a mutation of STK11 may be involved in progression of LEGH to MDA.

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Acknowledgments

This work was supported in part by Grants-in-aid for Scientific Research from the Ministry of Education, Science and Culture Japan (No. 22591851) and the Japan Society of Obstetrics and Gynecology.

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We have no conflict of financial interest.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, School of Medicine, Shinshu University, 3-1-1 Asahi, Matsumoto, 390-8621, Japan

    Akiko Takatsu, Tsutomu Miyamoto, Chiho Fuseya, Akihisa Suzuki, Hiroyasu Kashima, Akiko Horiuchi & Tanri Shiozawa

  2. Division of Diagnostic Pathology, Okaya City Hospital, 4-11-33 Honmachi, Okaya, 394-8512, Japan

    Keiko Ishii

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  1. Akiko Takatsu
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  2. Tsutomu Miyamoto
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Correspondence to Tsutomu Miyamoto.

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Takatsu, A., Miyamoto, T., Fuseya, C. et al. Clonality analysis suggests that STK11 gene mutations are involved in progression of lobular endocervical glandular hyperplasia (LEGH) to minimal deviation adenocarcinoma (MDA). Virchows Arch 462, 645–651 (2013). https://doi.org/10.1007/s00428-013-1417-1

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  • DOI: https://doi.org/10.1007/s00428-013-1417-1

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