Stage | Adjuvant treatment | Time to recurrence (months) | Site of recurrence | Treatment for recurrence | Post-recurrence survival (months) | Disease status | |
1 | IA | Observation | 45 | Groin, pelvic and PA LN | chemotherapy | 1.1 | AWD |
2 | IA | Observation | 48.6 | Pelvic mass | SX, chemotherapy | 125.6 | PDF* |
3 | IC | RT | 91 | PA LN | RT, chemotherapy | 90.5 | |
4 | IC | RT | 16 | Pelvic mass | SX | 34.1 | |
5 | IC | Observation | 24 | Pelvic mass | SX+RT | 5.4 | NED |
6 | IIC | Chemotherapy +RT | 21.6 | Lung nodules | Clinical trial | 29 | AWD |
7 | IC | Observation | 30.5 | PA LN | Observation† | 30 | AWD |
8 | IC | Observation | 21.8 | Pelvic mass | SX | 66.5 | |
9 | IA | Observation | 2.1 | ‡Diffuse abdopelvic carcinomatosis intra-abdominal masses and cardiophrenic LN | Chemotherapy | 96.8 | |
10 | II | Chemotherapy | 24.6 | Pelvic mass | RT | 42.9 | |
11 | III | Chemotherapy | 24.9 | Pelvic, PA and mediastinal LN | Clinical trial | 1.8 | AWD |
12 | IA | Chemotherapy | 82 | PA LN | SX | 5.4 | AWD |
13 | IC | Chemotherapy | 31.6 | Pelvic and PA LN | Chemotherapy | 29.1 | AWD |
NOT included in the table: two patients who were discharged to hospice and one patient who was lost to follow-up after recurrence.
*Died of stroke 10 years after recurrence, no evidence of disease.
†The patient refused treatment, the PA mass is slowly growing and monitored by imaging, with no signs of other disease sites.
‡Recurrence ascites was sent for cytology at time of recurrence, and reported as adenocarcinoma.
AWD, alive with disease; LN, lymph nodes;NED, no evidence of disease; PA, para-aortic; PDF, prolonged disease-free survival post-recurrence (no evidence of disease >30 months after recurrence); RT, radiation; SX, surgery.