Estimated sample size depending on true recurrence-free survival (RFS)
| Standard RFS | HRNIM | Experimental RFS | Absolute NIM | Total events (n) | Total sample size (n) |
| 85% | 1.568 | 77.5% | 7.5% | 127 | 768 |
| 87.5% | 1.671 | 80.0% | 7.5% | 97 | 712 |
| 90% | 1.826 | 82.5% | 7.5% | 72 | 656 |
NIM, non-inferiority margin; RFS, recurrence free survival; hazard ratio, HR ratio.