Table 1

Prevalence of germline B RCA1/2 (gBRCA1/2) mutation classified by patient background and ovarian factors

Classification factorsngBRCA mutation prevalence
PresentgBRCA1 mutation onlygBRCA2 mutation onlygBRCA1 and gBRCA2 mutationsAbsentVariant of uncertain significance
Patient factors
Age (years)
 <41414 (9.8)4 (9.8)0 (0.0)0 (0.0)36 (87.8)1 (2.4)
 ≥4159389 (15.0)59 (9.9)30 (5.1)0 (0.0)476 (80.3)28 (4.7)
Menopausal status
 Post-menopausal46270 (15.2)47 (10.2)23 (5.0)0 (0.0)369 (79.9)23 (5.0)
 Pre-menopausal16922 (13.0)15 (8.9)7 (4.1)0 (0.0)141 (83.4)6 (3.6)
 Unknown31 (33.3)1 (33.3)0 (0.0)0 (0.0)2 (66.7)0 (0.0)
Ovarian cancer factors
Cancer type (diagnosis by attending physician)
 Epithelial ovarian cancer53468 (12.7)47 (8.8)21 (3.9)0 (0.0)440 (82.4)26 (4.9)
 Primary peritoneal cancer5211 (21.2)9 (17.3)2 (3.8)0 (0.0)40 (76.9)1 (1.9)
 Fallopian tube carcinoma4814 (29.2)7 (14.6)7 (14.6)0 (0.0)32 (66.7)2 (4.2)
Histological category, atypia (centralized pathological diagnosis)
 All serous cancers27979 (28.3)54 (19.4)25 (9.0)0 (0.0)185 (66.3)15 (5.4)
 High-grade serous cancer27478 (28.5)53 (19.3)25 (9.1)0 (0.0)181 (66.1)15 (5.5)
 Low-grade serous cancer51 (20.0)1 (20.0)0 (0.0)0 (0.0)4 (80.0)0 (0.0)
 All mucinous cancers190 (0.0)0 (0.0)0 (0.0)0 (0.0)19 (100.0)0 (0.0)
 All endometrioid cancers1208 (6.7)7 (5.8)1 (0.8)0 (0.0)104 (86.7)8 (6.7)
 Clear-cell carcinoma1874 (2.1)2 (1.1)2 (1.1)0 (0.0)178 (95.2)5 (2.7)
 Seromucinous cancer40 (0.0)0 (0.0)0 (0.0)0 (0.0)4 (100.0)0 (0.0)
 Other252 (8.0)0 (0.0)2 (8.0)0 (0.0)22 (88.0)1 (4.0)
FIGO stage
 I2368 (3.4)3 (1.3)5 (2.1)0 (0.0)221 (93.6)7 (3.0)
 II717 (9.9)7 (9.9)0 (0.0)0 (0.0)60 (84.5)4 (5.6)
 III24462 (25.4)42 (17.2)20 (8.2)0 (0.0)170 (69.7)12 (4.9)
 IV8016 (20.0)11 (13.8)5 (6.3)0 (0.0)58 (72.5)6 (7.5)
 Other30 (0.0)0 (0.0)0 (0.0)0 (0.0)3 (100.0)0 (0.0)
  • Values are n (%).

  • CI, confidence interval;FIGO, International Federation of Gynecology and Obstetrics;gBRCA, germline BRCA.