Economic parameters used in the model
| Parameter | Cost (£) | 95% range | Source |
| Cost of screening | |||
| Sample collection | 15.31 | (12.5 to 18.63) | See online supplementary Appendix A5 |
| HPV test per sample* | 9.75 | (7.23 to 13.03) | See online supplementary Appendix A5 |
| Cytology test per slide* | 18.15 | (14.95 to 22.02) | See online supplementary Appendix A5 |
| Cost of treatment of neoplasias and cancers | |||
| Colposcopy | 151.18 | (124.18 to 184.08) | 14 |
| Biopsy | 79.84 | (65.35 to 97.71) | 15 |
| Excision | 382.6 | (313.89 to 468.41) | 14 |
| Hysterectomy | 2583.5 | (2222.28 to 3039.77 | 14 |
| Chemotherapy | 5089 | (4203.03 to 6188.00 | 16 |
| Trachalectomy | 5485.67 | (4500.32 to 6646.50 | 16 |
| Radiotherapy | 19 078 | (15 709.73 to 23 126.39 | 16 |
| Stage 1 | 4619 | (4105.25 to 5156.03 | 16 17 |
| Stage 2 | 20 704 | (17 927.10 to 23 509.72 | 16 17 |
| Stage 3 | 20 387 | (17 638.43 to 23 509.18 | 16 17 |
| Stage 4 | 17 320 | (14 953.77 to 20 008.25 | 16 17 |
| QALY loss per screening episode | |||
| Cytology normal, HPV negative | 0.0001 | (0.00002 to 0.00023) | 6–9 |
| Cytology low-grade, HPV negative, back to routine recall | 0.0011 | (0.00023 to 0.002) | |
| HPV positive, cytology normal, 12 month follow-up cytology | 0.004 | (0.00023 to 0.0089) | |
| Normal outcome at colposcopy | 0.0147 | (0.0015 to 0.04) | |
| CIN1 outcome at colposcopy | 0.0618 | (0.005 to 0.11) | |
| CIN2 outcome at colposcopy | 0.0783 | (0.003 to 0.13) | |
| Quality of life weight for different cancer stages | 18 19 | ||
| Stage I | 0.295 | (0.19 to 0.51) | |
| Stage II | 0.385 | (0.33 to 0.58) | |
| Stage III | 0.44 | (0.44 to 0.58) | |
| Stage IV | 0.52 | (0.4 to 0.64) | |
| Quality of life weight for different cancer stages post-treatment | |||
| Stage I | 0.03 | (0.01 to 0.27) | |
| Stage II | 0.065 | (0.02 to 0.32) | |
| Stage III | 0.065 | (0.02 to 0.32) | |
| Stage IV | 0.205 | (0.031 to 0.53) | |
*Includes consumables, equipment, staff time, and other overheads.
CIN, cervical intra-epithelial neoplasia; HPV, human papillomavirus; QOL, quality of life; QUALY, quality-adjusted life-years.