Dose level 1* | Dose level 2† | Dose level 3‡ | ||||
Toxicity grade | 3 | 4 | 3 | 4 | 3 | 4 |
Neutropenia | 0 | 0 | 0 | 1 | 0 | 2 |
Anemia | 0 | 0 | 0 | 0 | 0 | 0 |
Constitutional symptoms | 0 | 0 | 0 | 0 | 1 | 0 |
Pain | 0 | 0 | 0 | 0 | 0 | 2 |
Neuropathy | 0 | 0 | 0 | 0 | 0 | 0 |
Hypophosphatemia | 0 | 0 | 0 | 0 | 1 | 0 |
Hyponatremia | 0 | 0 | 0 | 0 | 0 | 1 |
Renal/genito-urinary | 0 | 0 | 0 | 0 | 1 | 0 |
Infection | 0 | 0 | 0 | 0 | 0 | 1 |
Gastrointestinal | 0 | 0 | 0 | 0 | 3 | 0 |
Dermatology | 0 | 0 | 0 | 0 | 1 | 0 |
Vascular | 0 | 0 | 0 | 0 | 1 | 0 |
*Oxaliplatin 75 mg/m2 IV and docetaxel 50 mg/m2 IP.
†Oxaliplatin 75 mg/m2 IV and docetaxel 75 mg/m2 IP.
‡Oxaliplatin 75 mg/m2 IV and docetaxel 100 mg/m2 IP.
IP, intraperitoneal; IV, intravenous.