Correlation between histological and molecular risk factors
| Class of risk* | POLE mutated | dMMR/MSI-H | p53 abnormal | NSMP |
| Low risk (n=93) | 2 (2.1%) | 23 (24.7%) | 6 (6.5%) | 62 (66.6%) |
| Intermediate risk (n=45) | 4 (8.9%) | 15 (33.3%) | 12 (26.7%) | 14 (31.1%) |
| Intermediate-high risk (n=40) | 4 (10%) | 14 (35%) | 6 (15%) | 16 (40%) |
| High risk (n=32) | 0 | 5 (15.6%) | 18 (56.3%) | 9 (28.1%) |
Data are reported as number (%).
*Classes of risk based on uterine risk factors according to the ESGO/ESTRO/ESP guidelines.
dMMR/MSI-H, mismatch repair deficient/microsatellite instability high; ESGO/ESTRO/ESP, European Society of Gynaecological Oncology/European SocieTy for Radiotherapy and Oncology/European Society of Pathology; NSMP, non-specific mutational profile; p53 abn, p53 abnormal; POLE, polymerase-epsilon.