Diagnostic performance of transrectal ultrasonography to detect pelvic node metastases separately in early and locally advanced stages of cervical cancer evaluated per patient
| Detection of pelvic node macrometastases only | ||||
| Early stages (n=267) 11 patients with macrometastases | Locally advanced stages (n=123) 43 patients with macrometastases | |||
| Results | 95% CI | Results | 95% CI | |
| Sensitivity | 18.2% | 0.0% to 41.0% | 86.0% | 75.7% to 96.4% |
| Specificity | 98.4% | 96.9% to 100.0% | 80.0% | 71.2% to 88.8% |
| PPV | 33.3% | 0.0% to 71.1% | 69.8% | 57.5% to 82.2% |
| NPV | 96.6% | 94.3% to 98.8% | 91.4% | 84.9% to 98.0% |
| ACC | 95.1% | 92.5% to 97.7% | 82.1% | 75.3% to 88.9% |
| AUC | 0.583 | 0.391 to 0.776 | 0.830 | 0.751 to 0.909 |
| DOR | 14.0 | 2.3 to 86.7 | 24.7 | 8.9 to 68.5 |
| Detection of pelvic node macrometastases and/or micrometastases (pN1) | ||||
| Early stages (n=267) 21 patients with pN1 | Locally advanced stages (n=123) 54 patients with pN1 | |||
| Results | 95% CI | Results | 95% CI | |
| Sensitivity | 9.5% | 0.0% to 22.1% | 70.4% | 58.2% to 82.5% |
| Specificity | 98.4% | 96.8% to 100.0% | 78.3% | 68.5% to 88.0% |
| PPV | 33.3% | 0.0% to 71.1% | 71.7% | 59.6% to 83.8% |
| NPV | 92.7% | 89.6% to 95.9% | 77.1% | 67.3% to 87.0% |
| ACC | 91.4% | 88.0% to 94.8% | 74.8% | 67.1% to 82.5% |
| AUC | 0.539 | 0.404 to 0.675 | 0.743 | 0.652 to 0.834 |
| DOR | 6.4 | 1.1 to 37.0 | 8.6 | 3.8 to 19.4 |
ACC, accuracy; AUC, area under curve; DOR, diagnostic OR ; NPV, negative predictive value; PPV, positive predictive value.