Multivariate binary logistic analysis
| BRCA | Age at mutation detection | BRCA1/2 mutation detection reason | |||||||||||||
| BRCA1 | BRCA2 | Adjusted OR (95% CI) | P value | <35 | ≥35 | Adjusted OR (95% CI) | P value | Family history * | Personal history | Adjusted OR (95% CI) | P value | Population screening | Adjusted OR (95% CI) | P value | |
| Risk reduction bilateral salpingo-oophorectomy | 159/295 (54%) | 95/179 (53%) | 0.78 (0.51 to 1.19) | 0.26 | 77/229 (34%) | 178/249 (71%) | 5.85 (3.83 to 8.94) | <0.001 | 211/385 (55%) | 13/19 (68%) | 1.81 (0.95 to 3.45) | 0.07 | 26/52 (50%) | 0.77 (0.26 to 2.24) | 0.63 |
| Hysterectomy | 23/271 (8%) | 21/160 (13%) | 1.31 (0.66 to 2.58) | 0.44 | 7/199 (4%) | 36/235 (15%) | 5.54 (2.26 to 13.59) | <0.001 | 34/351 (10%) | 1/21 (5%) | 0.92 (0.35 to 2.41) | 0.87 | 6/44 (14%) | 2.91 (0.37 to 22.75) | 0.31 |
| Risk reduction mastectomy | 109/289 (38%) | 43/170 (25%) | 1.66 (1.07 to 2.57) | 0.024 | 74/216 (34%) | 80/247 (32%) | 0.99 (0.65 to 1.49) | 0.95 | 133/370 (36%) | 12/24 (50%) | 4.75 (1.82 to 12.38) | 0.001 | 5/49 (10%) | 0.57 (0.25 to 1.32) | 0.19 |
*Family history is the reference group for OR calculation.