Table 1

Studies evaluating gynecologic oncology health-related quality of life (HRQoL) impact from the last 10 years

Study details	Cancer type	Participant information	HRQoL tools used	Outcomes	Conclusions
Malandrone et al48 (2022) Literature review	Vulval	n=300 studies	Mixture of QoL tools	Depressive and anxiety symptoms were more frequent Vulvar cancer may have a negative effect on sexuality (physical, psychological, and behavioral) Impact factors: shame, insecurity, or difficulties in self-care and daily activities	Need to better investigate this field and to identify strategies to relieve psychological distress
Roussin et al32 (2021) Systematic review of sexual quality of life (SQoL)	Mixed	n=46 studies	Mixture of QoL tools	SQoL varies across subgroups based on age, menopausal status, relationship status, and treatment modality Young, single, pre-menopausal women who underwent radiotherapy or radical surgeries have an increased risk for severe sexual dysfunction and psychosexual distress	A better understanding of factors of SQoL could protect and improve it More research needed dealing with psychosexual distress
Sehouli et al22 (2021) Prospective study of pre-operative QoL	Mixed (mostly ovarian cancer)	n=226 participants	EORTC QLQ-C30 NCCN DT	Impaired physical functioning (OR 5.08), being overweight or obese (OR 5.44), and a reduced Mini-Mental State Examination (OR 7.94) were predictive of severe post-operative complications Pre-operative QoL measurements could help predict post-operative complications	Investigate whether pre-operative symptom control can reduce the rate of post-operative complications and underline the need for prehabilitation approaches
Shisler et al41 (2018) Systematic review of PROs in gynecologic cancer	Endometrial cancer	n=27 studies	EORTC QLQ-C30 SF-36 FACT-G FSFI	Obesity associated with lower QoL and physical functioning Treatment type affects several QoL outcomes Sexual function outcomes were dependent on age, time since diagnosis, and consulting a physician before engaging in sexual activities A physical activity intervention improved sexual interest but not sexual function	Factors that contribute to QOL, such as pain, fatigue, emotional, and social functioning, should be monitored following an endometrial cancer diagnosis
Westin et al25 (2016) Cross-sectional survey QoL in USA	Mixed	n=1029 participants	Co-created local questionnaire (not validated)	The ten most common side effects were fatigue (44.3%), sexual dysfunction (35.7%), sleep disturbance (35.3%), neurologic symptoms (35.2%), urinary dysfunction (33.0%), bowel problems (31.2%), memory problems (30.8%), depression (26.4%), anxiety (19.3%), and lymphedema (17.6%)	Counsel patients regarding potential long-term medical issues related to the disease and cancer treatment
Smits et al28 (2015) Systematic review and meta-analysis of interventions to improve HRQoL	Endometrial and ovarian cancer	n=8 studies n=413 patients	Mixture of QoL tools	Lifestyle interventions may improve physical functioning, significantly reduce fatigue, and significantly increase weight loss in endometrial cancer survivors Lifestyle interventions in ovarian cancer survivors may result in QoL improvements	Further lifestyle intervention studies in the gynecological cancer population including on a long-term basis to determine its exact effect on QoL outcomes

DT, NCCN Distress Thermometer; FACT-G, Functional Assessment of Cancer Therapy-General; FSFI, Sexual Function Abbreviated Index; HADS, Hospital Anxiety and Depression Scale; HRQoL, health-related quality of life; OR, odds ratio; PRO, patient-reported outcome; EORTC QLQ-C30, European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire; QoL, quality of life; SF-36, 36-Item Short Form Survey (RAND 36-Item Health Survey) .