Table 4

Parameter coefficients from multivariable analysis of predictors of quality of life, evaluated separately for each of the functioning and symptom scales in the IPTW-adjusted cohort

Variables included in each multivariable model	Functioning scales*						Symptom scales†
Variables included in each multivariable model	Global QoL	Physical	Role	Emotional	Cognitive	Social	Fatigue	Pain
Intercept	90.97‡	138.49‡	126.18‡	73.39‡	87.70‡	99.58‡	4.59	−0.77
Age at survey (years, reference is age 0)	−0.08	−0.63‡	−0.41‡	0.25‡	0.13	−0.02	0.11	0.12
LEL and BMI category
No LEL and BMI <30 (reference)	0	0	0	0	0	0	0	0
No LEL and BMI 30–39.9	−6.52‡	−5.27‡	−2.89	−2.61	−1.92	−2.02	−0.32	−1.00
No LEL and BMI 40+	−6.42	−10.97‡	−7.33	−3.80	−4.00	−0.20	3.56	0.70
LEL and BMI <30	−6.94	−4.22	−12.47‡	−7.32	0.41	−4.54	10.03‡	9.03
LEL and BMI 30–39.9	−18.13‡	−15.74‡	−12.64‡	−8.17‡	−10.18‡	−13.75‡	18.83‡	19.48‡
LEL and BMI at 40+	−19.70‡	−33.08‡	−31.11‡	−13.24‡	−22.19‡	−30.66‡	19.97‡	29.26‡
History of diabetes at time of survey	0.44	−6.74‡	−3.60	−1.55	−5.58‡	−4.80	1.97	6.57‡
History of heart failure or congestive heart failure at time of survey	−6.25	−4.39	−0.48	1.74	6.21	1.44	0.07	−8.69
History of kidney disease or failure at time of survey	−16.60‡	−2.48	−0.91	−14.12‡	−12.07‡	−3.82	13.86‡	18.38‡
Therapy received as treatment for primary cancer or recurrence
None (reference)	0	0	0	0	0	0	0	0
EBRT alone	0.74	1.38	0.13	−2.00	−2.48	2.04	2.21	0.98
Chemotherapy±EBRT	0.28	−4.44	−3.15	−5.40	−10.24‡	−3.75	5.83	2.23
Type of staging
SLN biopsy (reference)	0	0	0	0	0	0	0	0
LND	2.87	0.59	0.35	5.14‡	0.79	2.53	−2.71	−1.83

QoL scores range from 0 to 100.
Bold indicates clinically meaningful difference (≥10 points).
*Higher functional scores indicate better functional well-being.
†Higher symptom scores indicate worse symptom.
‡Statistically significant, p<0.05.
BMI, body mass index (kg/m²) at time of survey; EBRT, external beam radiation therapy; IPTW, inverse-probability of treatment weighting; LEL, lower extremity lymphedema; LND, lymphadenectomy; QoL, quality of life; SLN, sentinel lymph node.