Univariate and multivariate Cox regression for factors associated with disease-free survival
| Characteristics | Univariate | Multivariate | ||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Diameter of tumor (cm) | ||||
| ≤2 | ||||
| >2 to ≤4 | 3.02 (0.92 to 9.91) | 0.069 | 2.83 (0.81 to 9.88) | 0.102 |
| >4 | 2.61 (0.75 to 9.01) | 0.130 | 2.46 (0.66 to 9.22) | 0.179 |
| Tumor grade | ||||
| Grade 1~2 | ||||
| Grade 3 | 1.01 (0.54 to 1.88) | 0.987 | 0.89 (0.46 to 1.74) | 0.742 |
| Depth of stromal invasion | ||||
| <1/2 | ||||
| ≥1/2 | 2.22 (0.94 to 5.22) | 0.069 | 1.51 (0.59 to 3.88) | 0.392 |
| LVSI | ||||
| No | ||||
| Yes | 1.16 (0.65 to 2.06) | 0.625 | 1.07 (0.59 to 1.96) | 0.815 |
| Parametrial involvement | ||||
| No | ||||
| Yes | 2.93 (1.24 to 6.90) | 0.014 | 1.28 (0.35 to 4.59) | 0.709 |
| Surgical margins | ||||
| Negative | ||||
| Positive | 2.56 (1.23 to 5.29) | 0.011 | 1.37 (0.44 to 4.27) | 0.589 |
| Vaginal involvement | ||||
| No | ||||
| Yes | 2.94 (1.46 to 5.91) | 0.003 | 3.13 (1.29 to 7.58) | 0.011 |
| Number of positive LN | ||||
| 1 | ||||
| ≥2 | 1.68 (0.92 to 3.08) | 0.090 | 1.29 (0.65 to 2.53) | 0.465 |
| Common iliac LN | ||||
| Negative | ||||
| Positive | 2.02 (1.03 to 3.96) | 0.042 | 1.49 (0.65 to 3.41) | 0.349 |
| Adjuvant treatment | ||||
| RT | ||||
| CCRT | 0.64 (0.27 to 1.50) | 0.303 | 0.48 (0.20 to 1.17) | 0.107 |
| SCRT | 0.45 (0.22 to 0.94) | 0.034 | 0.26 (0.11 to 0.57) | <0.001 |
CCRT, concurrent chemoradiation; LN, lymph node; LVSI, lymphovascular space invasion; RT, radiotherapy; SCRT, sequential chemoradiation.