Cellularity | High | High | High | High | High | N/A |
Architecture | 3D clusters to single cells | Trabecular to a nested | 3D clusters to single cells | Nested or nested and sheets | Small clusters and single cells | N/A |
N/C ratio | High | High | High | Moderate | High | N/A |
Nuclear Shape | Round to oval | Round to oval | Round to oval | Round to oval | Round to oval | N/A |
Nuclear Contour | Irregular | Irregular | Irregular | Smooth to slightly irregular | Irregular | N/A |
Nuclear Molding | Prominent | Prominent to Focal | not prominent | not prominent | Prominent | N/A |
Nuclear Pleomorphism | Moderate | Moderate | Significant | Mild | Moderate | N/A |
Chromatin Quality | Coarse to salt and pepper | Salt and pepper only | Coarse to salt and pepper | Salt and pepper only | Coarse to salt and pepper | N/A |
Naked Nuclei | Present | Absent | Present | Absent | Present | N/A |
Nucleoli | Absent | Rare single and small | Single small to intermediate | Rare single and small | Absent | N/A |
Mitotic Figures | Frequent | Frequent | Frequent | Frequent | Frequent | N/A |
Apoptotic Bodies | Significant | Significant | Significant | Rare to Absent | Significant | N/A |
Necrosis | Not readily identifiable | Not readily identifiable | Not readily identifiable | Readily identifiable | Absent | N/A |