Characteristic of patients with BM according to the BRCA status
| All patients with BM94 (100) | Patients with known BRCA status66 (100) | BRCAwt patients45 (100) | BRCAm patients 21 (100) | P value BRCAm vs BRCAwt | ||
|---|---|---|---|---|---|---|
| AGE at OC diagnosis Years, mean (SD) | 58.12 (10.68) | 58.16 (10.67) | 60.8 (10.48) | 52.52 (8.91) | 0.001 | |
| AGE at BM diagnosis Years, mean (SD) | 60.94 (10.26) | 61.21 (10.26) | 63.62 (9.94) | 56.04 (9.16) | 0.002 | |
| TIME OC-BM diagnosis Months, mean (SD) | 31.87 (24.27) | 34.39 (27) | 33.00 (28) | 37.38 (24.87) | 0.27 | |
| SITE OF BM No (%) | Cerebellum | 15 (16) | 10 (15.2) | 6 (13.3) | 4 (19.0) | 0.59 |
| Cerebrum | 46 (48.9) | 35 (53.0) | 23 (51.1) | 12 (57.1) | ||
| Mixed (+/- leptomeninges) | 33 (35.1) | 21 (31.8) | 16 (35.6) | 5 (23.8) | ||
| NUMBER OF BM No (%) | Single | 38 (40.4) | 26 (39.4) | 17 (37.8) | 9 (42.9) | 0.448 |
| Multiple | 56 (59.6) | 40 (60.6) | 28 (62.2) | 12 (57.1) | ||
| NEUROLOGICAL SYMPTOMS No (%) | YES | 50 (53.2) | 33 (50) | 25 (55.6) | 8 (38.1) | 0.145 |
| NO | 44 (46.8) | 33 (50) | 20 (44.4) | 13 (61.9) | ||
| CNS DISEASE ONLY No (%) | YES | 35 (37.2) | 23 (34.8) | 16 (35.6) | 7 (33.3) | 0.544 |
| NO | 59 (62.8) | 43 (65.2) | 29 (64.4) | 14 (66.7) | ||
| TYPE OF TREATMENT No (%) | Radiotherapy only | 15 (16) | 9 (13.6) | 7 (15.6) | 2 (9.5) | 0.33 |
| Chemotherapy only | 2 (2.1) | 1 (1.5) | 0 (0) | 1 (4.8) | ||
| Surgery only | 3 (3.2) | 3 (4.5) | 2 (4.4) | 1 (4.8) | ||
| Chemotherapy + Radiotherapy or Surgery | 43 (45.7) | 30 (45.5) | 18 (40) | 12 (57.1) | ||
| Radiotherapy + Surgery | 9 (9.6) | 7 (10.6) | 6 (13.3) | 1 (4.8) | ||
| Chemotherapy + Radiotherapy + Surgery | 17 (18.1) | 11 (16.7) | 7 (15.6) | 4 (19) | ||
| None | 5 (5.3) | 5 (7.6) | 5 (11.1) | 0 (0) | ||