Table 5

Breakthrough hypersensitivity reaction characteristics

Characteristicn=79
Median desensitization cycle for repeat HSR (range)1 (1–8)
HSR grade
 16 (8%)
 237 (47%)
 331 (39%)
 44 (5%)
 Unknown1 (1%)
Symptoms and signs
 Erythema75 (95%)
 Urticaria57 (72%)
 Flushing49 (62%)
 Pruritus44 (56%)
 Dyspnea38 (48%)
Epinephrine administered4 (5%)
Transfer to urgent care/emergency department6 (8%)
Same-day rechallenge*30 (38%)
  • *Rechallenged on the same day after breakthrough HSR occurred, following assessment by the treating clinician and appropriate medical intervention.

  • HSR, hypersensitivity reaction.