Table 1

Example of the outpatient 12-step Memorial Sloan Kettering Cancer Center desensitization protocol

Bag number
(total volume)
Percent of total doseStepInfusion rate for long infusion
(mL/hour)
Infusion rate for short infusion
(mL/hour)
Time per step
(min)
Bag 1
(250 mL)
1%12415
251015
3102015
4204015
Discard remainder of bag. If no reaction, proceed to bag 2.
Bag 2
(63 mL)
2.5%551015
6102015
7204015
8408015
Discard remainder of bag. If no reaction, proceed to bag 3.
Bag 3
(250 mL)
96.5%9102015
10204015
11408015
1275150186 (long)
86 (short)
  • If no reaction in step 12, infuse remainder of bag at 75 mL/hour (long infusion) or 150 mL/hour (short infusion).

  • Total infusion time: 351 min (long infusion) or 251 min (short infusion).