Table 3

Ongoing trials of investigational therapies for locally advanced cervical cancer using concurrent chemoradiotherapy as a backbone

Trial name/ identification	Investigational therapy	Concurrent chemoradiotherapy regimen	Phase
	*Immune checkpoint inhibitors*
CALLA NCT03830866	Durvalumab vs placebo Concurrent with chemoradiotherapy and adjuvant	Weekly platinum-based chemotherapy + external beam radiation therapy, then brachytherapy	III
KEYNOTE-A18 NCT04221945	Pembrolizumab vs placebo Concurrent with chemoradiotherapy and adjuvant	Weekly cisplatin + external beam radiation therapy, then brachytherapy	III
ATEZOLACC NCT03612791	Atezolizumab vs standard of care Concurrent with chemoradiotherapy and adjuvant	Weekly cisplatin + external beam radiation therapy, then brachytherapy	II
BrUOG 355 NCT03527264	Nivolumab Concurrent with chemoradiotherapy Adjuvant to chemoradiotherapy Concurrent with chemoradiotherapy and adjuvant	Weekly cisplatin + external beam radiation therapy*	II
NCT02635360	Pembrolizumab Concurrent with chemoradiotherapy Adjuvant to chemoradiotherapy	Weekly cisplatin, then brachytherapy only	II
NCT03738228	Atezolizumab Neoadjuvant and concurrent with chemoradiotherapy Concurrent with chemoradiotherapy	Weekly cisplatin + external beam radiation therapy, then brachytherapy	I
	*Antiangiogenic therapies*
NCT04138992	Bevacizumab vs standard of care Neoadjuvant bevacizumab + chemotherapy and concurrent with chemoradiotherapy Concurrent with chemoradiotherapy	Weekly cisplatin + external beam radiation therapy, then brachytherapy	II/III
NCT04121975	Endostar Concurrent with chemoradiotherapy	Weekly cisplatin + external beam radiation therapy	II
	*Ribonuclease reductase inhibitor*
NCT02466971	Triapine vs standard of care Concurrent with chemoradiotherapy	Weekly cisplatin + external beam radiation therapy, then brachytherapy	III
	*HPV vaccine*
IMMUNOCERV NCT04580771	PDS0101 Concurrent with chemoradiotherapy and adjuvant	Weekly cisplatin + radiotherapy*	II
	*Radiosensitizing nanoparticle*
NANOCOL NCT03308604	AGuIX Concurrent with radiotherapy	Weekly cisplatin + external beam radiation therapy, then brachytherapy	I

All information gathered from clinicaltrials.gov.
*Brachytherapy not specified.
HPV, human papillomavirus.