Table 3

Ongoing trials of investigational therapies for locally advanced cervical cancer using concurrent chemoradiotherapy as a backbone

Trial name/ identificationInvestigational therapyConcurrent chemoradiotherapy regimenPhase
Immune checkpoint inhibitors
CALLA
NCT03830866
Durvalumab vs placebo
  • Concurrent with chemoradiotherapy

    and adjuvant

Weekly platinum-based chemotherapy + external beam radiation therapy, then brachytherapyIII
KEYNOTE-A18
NCT04221945
Pembrolizumab vs placebo
  • Concurrent with chemoradiotherapy

    and adjuvant

Weekly cisplatin + external beam radiation therapy, then brachytherapyIII
ATEZOLACC
NCT03612791
Atezolizumab vs standard of care
  • Concurrent with chemoradiotherapy

    and adjuvant

Weekly cisplatin + external beam radiation therapy, then brachytherapyII
BrUOG 355
NCT03527264
Nivolumab
  • Concurrent with chemoradiotherapy

  • Adjuvant to chemoradiotherapy

  • Concurrent with chemoradiotherapy

    and adjuvant

Weekly cisplatin + external beam radiation therapy*II
NCT02635360Pembrolizumab
  • Concurrent with chemoradiotherapy

  • Adjuvant to chemoradiotherapy

Weekly cisplatin, then brachytherapy onlyII
NCT03738228Atezolizumab
  • Neoadjuvant and concurrent with chemoradiotherapy

  • Concurrent with chemoradiotherapy

Weekly cisplatin + external beam radiation therapy, then brachytherapyI
Antiangiogenic therapies
NCT04138992Bevacizumab vs standard of care
  • Neoadjuvant bevacizumab + chemotherapy and concurrent with chemoradiotherapy

  • Concurrent with chemoradiotherapy

Weekly cisplatin + external beam radiation therapy, then brachytherapyII/III
NCT04121975Endostar
  • Concurrent with chemoradiotherapy

Weekly cisplatin + external beam radiation therapyII
Ribonuclease reductase inhibitor
NCT02466971Triapine vs standard of care
  • Concurrent with chemoradiotherapy

Weekly cisplatin + external beam radiation therapy, then brachytherapyIII
HPV vaccine
IMMUNOCERV
NCT04580771
PDS0101
  • Concurrent with chemoradiotherapy

    and adjuvant

Weekly cisplatin + radiotherapy*II
Radiosensitizing nanoparticle
NANOCOL
NCT03308604
AGuIX
  • Concurrent with radiotherapy

Weekly cisplatin + external beam radiation therapy, then brachytherapyI
  • All information gathered from clinicaltrials.gov.

  • *Brachytherapy not specified.

  • HPV, human papillomavirus.