Table 2

HPV-independent cervical cancer reports

AuthorSample histologyNegative cases
N (%)
Negative results according to sample histologyTechnique
Riou et al48 89 SQ, 17 ADC17/106 (16.03)15 SQ, 2 ADCSouthern blot, PCR
Shikano et al32 39 ADC14/39 (14.35)14 ADCCISH
Brewer et al34 30 LCNK, 23 LCK, 7 ADC, 5 ADS, 1 CC5/66 (7.57)Not reportedMY09/11 – E6
Lo et al51 107 SQ, 14 ADC26/121 (21.48)23 SQ, 3 ADCMY09/11 - sequencing
Kedzia et al33 47 SQ15/47 (31.91)15 SQMY09/11 – E6
Park et al35 26 ADC unusuals26/26 (100)26 ADC unusualsSPF10-LiPA system
Xu et al39 13 SQ, 25 ADC17/38 (44.73)4 SQ, 13 ADCMultiplex PCR
Liu et al40 89 SQ, 10 ADC, 2 CC, 1 undifferentiated14/101 (13.86)Not reported E6/E7 mRNA
Rodríguez-Carunchio et al50 104 SQ, 32 ADC8/136 (5.88)3 SQ, 5 ADCHC2, SPF10-LiPA system, GP5+/6+, E7-specific assay
Omori et al36 36 ADC usual, 8 ADC gastric14/44 (31.81)6 ADC usuals, 8 ADC gastricsISH, PCR
Park et al31 50 SQ, 2 ADC15/52 (28.84)Not reported E6/E7 mRNA
Burk et al4 144 SQ, 31 ADC, 3 ADS9/178 (5.05)4 SQ, 5 ADCRNA seq
Banister et al42 212 SQ, 44 ADC, 5 ADS20/261 (7.70)10 SQ, 8 ADC, 2 ADSRNA seq (E6E7/total genes)
Chong et al52 210 SQ, 38 ADC/ADS46/248 (18.50)33 SQ, 13 ADC/ADSPAN Array HPV Genotyping Chip/Anyplex II HPV28
Nicolás et al37 168 SQ, 39 ADC, 4 ADS, 3 neuroendocrines21/214 (9.81)12 SQ, 6 ADC, 1 ADS, 2 neuroendocrinesSPF10-LiPA system
Kaliff et al55 169 SQ, 27 ADC, 4 ADS, 2 neuroendocrines14/202 (6.9)3 SQ, 9 ADC, 2 ADSAnyplex II HPV28, RT-PCR E6/E7
  • ADC, adenocarcinoma; ADS, adenosquamous; CC, clear cells; CISH, chromogenic in situ hybridization; HPV, human papillomavirus; ISH, in situ hybridization; LCK, large cell keratinizing; LCNK, large cell non-keratinizing; PCR, polymerase chain reaction; SQ, squamous.