Stage III, IV, or recurrent, histologically confirmed endometrial carcinoma with measurable or radiographically apparent disease* Prior therapies may include chemotherapy (only if administered as neoadjuvant or adjuvant therapy and/or concurrently with radiation), radiation, or hormonal therapy (only if discontinued ≥1 week before randomization) Provided archival tumor tissue or newly obtained biopsy of tumor for determination of mismatch repair status Eastern Cooperative Oncology Group performance status of 0/1
| Carcinosarcoma, endometrial leiomyosarcoma, or other high grade sarcomas, or endometrial stromal sarcomas Additional malignancies that have progressed or required active treatment in the last 3 years† Gastrointestinal conditions that might affect absorption of lenvatinib Active infection requiring systemic treatment Previous therapy with any treatment targeting vascular endothelial growth factor-directed angiogenesis; anti-PD-1, anti-PD-L1, or anti-PD-L2 agents; or any agent directed at another stimulatory or co-inhibitory T cell receptor Inadequate organ function
|