Characteristics of cohort
| T1a1 L1(N=208) | T1a2(N=102) | T1b1 ≤2cm(N=356) | T1b >2cm(N=41) | T1b2(N=19) | T2(N=7) | p-value | |||
|---|---|---|---|---|---|---|---|---|---|
| Parity before diagnosis | |||||||||
| Nullipara | 125 (60.1%) | 66 (64.7%) | 250 (70.2%) | 24 (58.5%) | 14 (73.7%) | 5 (71.4%) | 0.162 | ||
| Primipara | 54 (26.0%) | 27 (26.5%) | 82 (23.0%) | 15 (36.6%) | 4 (21.1%) | 2 (28.6%) | |||
| Multipara | 29 (13.9%) | 9 (8.8%) | 24 (6.7%) | 2 (4.9%) | 1 (5.3%) | 0 (0.0%) | |||
| Age at first diagnosis of cervical cancer [years ] | |||||||||
| mean (SD) | 33.1 (4.7) | 33.2 (4.4) | 31.7 (4.5) | 30.8 (3.4) | 29.4 (5.1) | 33.1 (5.2) | <0.001 | ||
| median (5–95th percentile) | 32.7 (25.9–40.8) | 33.0 (27.4–40.0) | 31.9 (24.4–39.3) | 30.5 (26.2–36.5) | 28.8 (19.3–38.8) | 31.4 (27.0–42.8) | |||
| Diagnostic procedure | |||||||||
| Biopsy | 56 (26.9%) | 23 (22.5%) | 139 (39.0%) | 24 (58.5%) | 15 (78.9%) | 5 (71.4%) | <0.001 | ||
| Conization | 131 (63.0%) | 78 (76.5%) | 212 (59.6%) | 16 (39.0%) | 3 (15.8%) | 2 (28.6%) | |||
| Pap smear | 14 (6.7%) | 1 (1.0%) | 4 (1.1%) | 1 (2.4%) | 0 (0.0%) | 0 (0.0%) | |||
| Histological type | |||||||||
| Adenocancer | 39 (18.8%) | 25 (24.5%) | 101 (28.4%) | 9 (22.0%) | 3 (15.8%) | 1 (14.3%) | 0.214 | ||
| Adenosquamous | 7 (3.4%) | 4 (3.9%) | 20 (5.6%) | 1 (2.4%) | 2 (10.5%) | 0 (0.0%) | |||
| Squamous | 161 (77.4%) | 73 (71.6%) | 232 (65.2%) | 30 (73.2%) | 13 (68.4%) | 6 (85.7%) | |||
| Other | 1 (0.5%) | 0 (0.0%) | 3 (0.8%) | 0 (0.0%) | 1 (5.3%) | 0 (0.0%) | |||
| Lymphovascular space invasion | n=173 | n=92 | n=318 | n=41 | n=18 | n=4 | |||
| No | 0 (0%) | 69 (75.0%) | 213 (67.0%) | 25 (61.0%) | 7 (38.9%) | 1 (25.0%) | <0.001 | ||
| Yes | 173 (100%) | 23 (25.0%) | 105 (33.0%) | 16 (39.0%) | 11 (61.1%) | 3 (75.0%) | |||
| Neoadjuvant chemotherapy | |||||||||
| No | 207 (99.5%) | 102 (100.0%) | 330 (92.7%) | 34 (82.9%) | 11 (57.9%) | 2 (28.6%) | <0.001 | ||
| Yes | 1 (0.5%) | 0 (0.0%) | 26 (7.3%) | 7 (17.1%) | 8 (42.1%) | 5 (71.4%) | |||
| Type of surgical treatment | |||||||||
| Cervical procedure | 208 (100.0%) | 102 (100.0%) | 356 (100.0%) | 41 (100.0%) | 19 (100.0%) | 7 (100.0%) | - | ||
| Repeated cervical procedure | 76 (36.5%) | 20 (19.6%) | 70 (19.7%) | 4 (9.8%) | 4 (21.1%) | 0 (0.0%) | <0.001 | ||
| Sentinel lymph node biopsy | 55 (26.4%) | 44 (43.1%) | 171 (48.0%) | 15 (36.6%) | 9 (47.4%) | 2 (28.6%) | <0.001 | ||
| Pelvic lymphadenectomy | 52 (25.0%) | 81 (79.4%) | 310 (87.1%) | 32 (78.0%) | 17 (89.5%) | 5 (71.4%) | <0.001 | ||
| Paraaortic lymphadenectomy | 5 (2.4%) | 1 (1.0%) | 15 (4.2%) | 0 (0.0%) | 3 (15.8%) | 0 (0.0%) | 0.054 | ||
| Cerclage placement | 22 (10.6%) | 26 (25.5%) | 106 (29.8%) | 13 (31.7%) | 3 (15.8%) | 1 (14.3%) | <0.001 | ||
| Type of cervical procedure | |||||||||
| Conization | 151 (72.6%) | 54 (52.9%) | 133 (37.4%) | 5 (12.2%) | 7 (36.8%) | 2 (28.6%) | <0.001 | ||
| Laparoscopic radical trachelectomy | 1 (0.5%) | 13 (12.7%) | 30 (8.4%) | 3 (7.3%) | 0 (0.0%) | 1 (14.3%) | |||
| Radical abdominal trachelectomy | 18 (8.7%) | 17 (16.7%) | 93 (26.1%) | 21 (51.2%) | 5 (26.3%) | 3 (42.9%) | |||
| Radical vaginal trachelectomy | 18 (8.7%) | 6 (5.9%) | 67 (18.8%) | 5 (12.2%) | 3 (15.8%) | 0 (0.0%) | |||
| Robotic radical trachelectomy | 1 (0.5%) | 5 (4.9%) | 6 (1.7%) | 2 (4.9%) | 1 (5.3%) | 0 (0.0%) | |||
| Simple vaginal trachelectomy | 19 (9.1%) | 7 (6.9%) | 27 (7.6%) | 5 (12.2%) | 3 (15.8%) | 1 (14.3%) | |||
| Recurrence | |||||||||
| No | 192 (92.3%) | 96 (94.1%) | 321 (90.2%) | 33 (80.5%) | 14 (73.7%) | 7 (100.0%) | 0.028 | ||
| Yes | 16 (7.7%) | 6 (5.9%) | 35 (9.8%) | 8 (19.5%) | 5 (26.3%) | 0 (0.0%) | |||
| Type of recurrence | |||||||||
| Pre-cancer | 8 (3.8%) | 5 (4.9%) | 9 (2.5%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0.623 | ||
| Invasive cancer | 9 (4.3%) | 2 (2.0%) | 27 (7.6%) | 8 (19.5%) | 5 (26.3%) | 0 (0.0%) | <0.001 | ||