Overall frequency of most studied mutations in the included studies
| Gene | N | Number of VSCC assessed | Overall frequency | Frequency range | Number of articles |
|---|---|---|---|---|---|
| TP53 | 387 | 711 | 54,43% | 33-79% | 13 |
| PIK3CA | 112 | 711 | 15,75% | 0-34% | 13 |
| HRAS | 60 | 677 | 8,86% | 0-28% | 11 |
| CDKN2A | 156 | 610 | 25,57% | 6-36% | 9 |
| PTEN | 26 | 646 | 4,02% | 0-6% | 9 |