Univariate analysis of factors associated with disease-free survival (N = 969)
| Predictor | Category | n | HR (95% CI) | p-value |
|---|---|---|---|---|
| Surgical approach | Open | 575 | Ref. | |
| Robotic | 195 | 1.21 (0.74; 1.97) | 0.439 | |
| Laparoscopic | 141 | 1.51 (0.93; 2.45) | 0.097 | |
| Combined | 58 | 1.06 (0.48; 2.31) | 0.888 | |
| Tumour diameter | < 0.5 cm | 73 | Ref. | |
| 0.5–1.99 cm | 424 | 1.67 (0.51; 5.47) | 0.399 | |
| 2–3.99 cm | 376 | 3.98 (1.25 ; 12.69) | 0.019 | |
| ≥ 4 cm | 96 | 6.35 (1.91 ; 21.13) | 0.003 | |
| LVSI | No | 316 | Ref. | |
| Yes | 351 | 2.31 (1.47 ; 3.63) | < 0.001 | |
| Tumour histotype | Squamous | 605 | Ref. | |
| Adenocarc. | 287 | 1.13 (0.75; 1.71) | 0.554 | |
| Adenosquamous | 50 | 1.38 (0.66; 2.89) | 0.385 | |
| Other | 27 | 3.03 (1.45 ; 6.31) | 0.003 | |
| Grade | 1 | 149 | Ref. | |
| 2 | 406 | 2.08 (1.02 ; 4.22) | 0.044 | |
| 3 | 246 | 3.35 (1.64 ; 6.85) | < 0.001 | |
| Largest type of metastasis in LN | Negative | 795 | Ref. | |
| ITC | 31 | 1.67 (0.68; 4.14) | 0.264 | |
| MIC | 59 | 2.55 (1.47 ; 4.43) | < 0.001 | |
| MAC | 84 | 2.36 (1.44 ; 3.87) | < 0.001 | |
| Largest type of metastasis in LN | Negative | 795 | Ref. | |
| ITC | 31 | 1.67 (0.68; 4.14) | 0.264 | |
| MIC+MAC | 143 | 2.44 (1.63 ; 3.64) | < 0.001 | |