Table 1

Summary recommendations for post-operative therapy

Disease setting	Target	Adjuvant therapy	Level of evidence
Early stage Including disease confined to a polyp at hysterectomy	ND	Chemotherapy* (preferred)	Retrospective, population-based data
	ND	VBT	Retrospective, population-based data
Advanced stage	HER2+	Chemotherapy*+trastuzumab	Prospective, randomized data
	ND and HER2−	Chemotherapy*	Prospective, randomized data
	ND and HER2−	EBRT for selected cases	Retrospective, population-based data
Recurrent disease	HER2+	Chemotherapy*+trastuzumab	Prospective, randomized data
	HER2+	Adavosertib
	HER2−	Chemotherapy
	HER2−	Adavosertib
	MSI	Pembrolizumab
	MSS	Pembrolizumab+ Lenvatinib

*Doublet of paclitaxel and carboplatin.
EBRT, external beam radiotherapy; MSI, microsatellite instable; MSS, microsatellite stable; ND, not defined; VBT, vaginal brachytherapy.