Table 3A

Univariate associates

Variable		Overall survival		Locoregional failure		Any failure
Variable		HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
Age at diagnosis	per 10 years	2.85 (1.87 to 4.36)	<0.001*	1.82 (0.74 to 4.49)	0.19	2.05 (1.15 to 3.66)	0.015*
Age at diagnosis	≥65	3.51 (1.54 to 8.02)	0.003*	4.17 (0.50 to 34.63)	0.19	3.31 (0.95 to 11.51)	0.06
Age at diagnosis	<65	Reference		Reference		Reference
Pathology	Clear Cell	1.52 (0.44 to 5.20)	0.69	1.53 (0.14 to 16.90)	0.62	1.27 (0.30 to 5.32)	0.25
	Serous	1.07 (0.37 to 3.09)		0.65 (0.07 to 5.95)		0.52 (0.14 to 1.96)
	Mixed	Reference		Reference		Reference
FIGO stage	IA	Reference	0.36	Reference	0.87	Reference	0.42
FIGO stage	IB	1.48 (0.65 to 3.38)		1.19 (0.14 to 9.88)		0.44 (0.06 to 3.30)
Lymphovascular Space Invasion	Positive	1.80 (0.85 to 3.85)	0.13	1.35 (0.26 to 6.99)	0.72	0.81 (0.23 to 2.84)	0.74
Lymphovascular Space Invasion	Negative	Reference		Reference		Reference
Size	per 1 cm	1.42 (1.15 to 1.76)	<0.001*	1.91 (1.20 to 3.02)	0.006*	1.56 (1.16 to 2.08)	0.003*
Size	≥3.5 cm	2.88 (1.42 to 5.84)	0.003*	7.02 (0.85 to 58.38)	0.07	3.83 (1.25 to 11.75)	0.019
Size	<3.5 cm	Reference		Reference		Reference
Polyp confined	No	Reference	0.90	Reference	0.72	Reference	0.89
Polyp confined	Yes	1.07 (0.38 to 3.03)		0.57 (0.03 to 12.20)		1.11 (0.25 to 4.86)
Cytology	Positive	2.18 (0.88 to 5.45)	0.09	1.41 (0.16 to 12.29)	0.76	4.36 (1.53 to 12.43)	0.006*
Cytology	Negative	Reference		Reference		Reference
Chemotherapy delivery	No	1.16 (0.58 to 2.33)	0.67	9.72 (0.45 to 209.1)	0.15	3.13 (0.90 to 10.90)	0.07
Chemotherapy delivery	Yes	Reference		Reference		Reference
Surgery to first implant	≤6 weeks	1.39 (0.69 to 2.81)	0.36	1.14 (0.25 to 5.20)	0.86	0.62 (0.23 to 1.64)	0.33
Surgery to first implant	>6 weeks	Reference		Reference		Reference

Bold font indicates statistical significance.
*Remained significant on multivariate analysis.
FIGO, International Federation of Gynecology and Obstetrics.