Performance of screening scenarios according to triage strategies stratified by referral rates to treatment or colposcopy, histology results, over-treatment or over-referral rates to colposcopy, and number of treatments or colposcopies per CIN2+
| One-visit scenario and triage strategy* | HPV-positive women (triage) | Referred for treatment | Histology <CIN2 | Histology CIN2+ | Over-treatment | Women treated per CIN2+ |
| VA | 286 | 168/286 (58.7%) | 141 | 27 | 141/168 (83.9%) | 6.2 |
| Genotyping and reflex VA | 286 | 192/286 (67.1%) | 163 | 29 | 163/192 (84.8%) | 6.6 |
| Two-visit scenario and triage strategy† | Referred for colposcopy | Histology <CIN2 | Histology ≥CIN2 | Over-referral to colposcopy | Women referred per CIN2+ | |
| Manual LBC | 276 | 51/276 (18.5%) | 23 | 28 | 23/51 (45.0%) | 1.8 |
| Genotyping and reflex manual LBC | 279 | 95/279 (34.4%) | 66 | 29 | 66/95 (69.4%) | 3.3 |
| Automated LBC | 253 | 91/253 (36.0%) | 63 | 28 | 63/91 (69.2%) | 3.2 |
| Genotyping and reflex automated LBC | 263 | 133/263 (50.6%) (50.6%) | 102 | 31 | 102/133 (76.7%) (76.7%) | 4.3 |
*Suitable for low-income countries.
†Suitable for middle-income countries.
CIN2+, cervical intraepithelial neoplasia grade 2 or worse; <CIN2, cervical intraepithelial neoplasia grade 1 or negative; LBC, liquid-based cytology; VA, visual assessment.