Diagnostic performance of single and combined triage tests for CIN2+ and CIN3+ detection among HPV-positive women
| Variable | CIN2+ (n=35, 12.2%) | |||
| Sensitivity | Specificity | PPV | NPV | |
| % (95% CI) | % (95% CI) | % (95% CI) | % (95% CI) | |
| Single test triage | ||||
| VA | 77.1 (59.5 to 88.6) | 43.8 (37.7 to 50.0) | 16.1 (11.2 to 22.5) | 93.2 (86.9 to 96.6) |
| Manual LBC | 80.0 (62.6 to 90.5) | 90.4 (86.0 to 93.6) | 54.9 (40.8 to 68.3) | 96.9 (93.5 to 98.5) |
| Automated LBC | 84.8 (67.2 to 93.9) | 71.4 (64.5 to 76.9) | 30.8 (22.0 to 41.1) | 96.9 (92.7 to 98.7) |
| HPV-16/HPV-18/45 genotyping | 37.1 (22.3 to 54.9) | 79.7 (74.2 to 84.2) | 20.3 (12.0 to 32.3) | 90.1 (85.4 to 93.4) |
| Combined test triage | ||||
| Genotyping and reflex VA | 82.9 (65.7 to 92.4) | 35.1 (29.3 to 41.2) | 15.1 (10.7 to 21.0) | 93.6 (86.3 to 91.7) |
| Genotyping and reflex manual LBC | 85.7 (68.9 to 94.2) | 73.0 (67.0 to 78.2) | 31.3 (22.7 to 41.4) | 97.3 (93.6 to 98.9) |
| Genotyping and reflex automated LBC | 91.2 (74.8 to 97.3) | 55.5 (48.9 to 61.8) | 23.3 (16.8 to 31.4) | 97.7 (93.0 to 99.3) |
| CIN3+ (n=22, 7.7%) | ||||
| Sensitivity | Specificity | PPV | NPV | |
| % (95% CI) | % (95% CI) | % (95% CI) | % (95% CI) | |
| Single test triage | ||||
| VA | 72.7 (49.0 to 88.1) | 42.4 (36.6 to 48.5) | 9.5 (5.9 to 15.0) | 94.9 (89.0 to 97.7) |
| Manual LBC | 90.9 (67.3 to 97.9) | 87.8 (83.1 to 91.3) | 39.2 (26.5 to 53.6) | 99.1 (96.5 to 99.8) |
| Automated LBC | 85.0 (59.6 to 95.6) | 68.2 (61.9 to 73.9) | 18.7 (11.8 to 28.2) | 98.1 (94.3 to 99.4) |
| HPV-16/HPV-18/45 genotyping | 45.5 (25.1 to 67.5) | 79.5 (74.2 to 84.0) | 15.6 (8.5 to 27.0) | 94.6 (90.7 to 96.9) |
| Combined test triage | ||||
| Genotyping and reflex VA | 81.8 (58.1 to 93.6) | 34.1 (28.6 to 40.1) | 9.4 (5.9 to 14.4) | 95.7 (89.0 to 98.4) |
| Genotyping and reflex manual LBC | 95.5 (70.4 to 99.5) | 70.8 (64.9 to 76.0) | 21.9 (14.6 to 31.4) | 99.5 (96.2 to 99.9) |
| Genotyping and reflex automated LBC | 95.2 (69.1 to 99.4) | 53.3 (47.0 to 59.6) | 15.0 (9.9 to 22.3) | 99.2 (94.6 to 99.9) |
.CIN2+, cervical intraepithelial neoplasia grade 2 or worse; CIN3+, cervical intraepithelial neoplasia grade 3 or worse; HPV, human papillomavirus; LBC, liquid-based cytology; NPV, negative predictive value; PPV, positive predictive value; VA, visual assessment.