Characteristic | Overall cohort (n=100) | Parametrial involvement (n=10) | No parametrial involvement (n=90) | P value |
Age, median (range), years | 35.0 (22.0–65.0) | 41.5 (30.0–63.0) | 35.0 (22.0–65.0) | 0.06 |
BMI, median (range), kg/m2 | 25.1 (14.4–60.5) | 25.3 (16.7–32.8) | 25.1 (14.4–60.5) | 0.43 |
Current or former smoker | 0.48 | |||
Yes | 43 (43) | 6 (60) | 37 (41) | |
No | 56 (56) | 4 (40) | 52 (58) | |
Not reported | 1 (1) | 0 (0) | 1 (1) | |
FIGO (2018) stage | ||||
IA1, IA2 | 11 (11) | 0 (0) | 11 (12) | |
IB1 | 43 (43) | 0 (0) | 43 (48) | |
IB2 | 23 (23) | 0 (0) | 23 (26) | |
IIA1 | 1 (1) | 0 (0) | 1 (1) | |
IIB | 2 (2) | 2 (20) | 0 (0) | |
IIIC1p | 20 (20) | 8 (80) | 12 (13) | |
Histology† | 0.46 | |||
Pure HGNECC | 51 (51) | 4 (40) | 47 (52) | |
Mixed (HGNECC+other histology) | 49 (49) | 6 (60) | 43 (48) | |
Pre-treatment tumor size | 0.05 | |||
≤2 cm | 48 (48) | 2 (20) | 46 (51) | |
>2 cm | 47 (47) | 8 (80) | 39 (43) | |
Not reported | 5 (5) | 0 (0) | 5 (6) | |
Tumor size in surgical specimen | 0.06 | |||
No residual disease | 19 (19) | 0 (0) | 19 (21) | |
≤2 cm | 27 (27) | 2 (20) | 25 (28) | |
>2 cm and ≤4 cm | 41 (41) | 7 (70) | 34 (38) | |
>4 cm | 2 (2) | 1 (10) | 1 (1) | |
Not reported | 11 (11) | 0 (0) | 11 (12) | |
Positive nodes | 20/94 (21) | 8/10 (80) | 12/84 (14) | <0.0001 |
Number of positive nodes, median (range) | 2.0 (1.0–6.0) | 2.0 (1.0–4.0) | 2.0 (1.0–6.0) | 0.49 |
Depth of invasion | 0.13 | |||
≤10 mm | 49/72 (68) | 4/9 (44) | 45/63 (71) | |
>10 mm | 23/72 (32) | 5/9 (56) | 18/63 (29) | |
Lymphovascular space invasion | 0.11 | |||
No | 19/24 (19) | 0/10 (0) | 19/69 (28) | |
Yes | 60/79 (76) | 10/100 (100) | 50/69 (72) | |
Positive vaginal margin | 3 (3) | 2 (20) | 1 (1) | 0.03 |
Ovarian compromise‡ | 1/57 (2) | 0/6 (0) | 1/51 (2) | 1 |
*Results reported as number of patients (%) except when otherwise specified.
†Final histology: combination of pre-treatment histology and final specimen pathology.
‡Only reported for patients with bilateral salpingo-oophorectomy or unilateral oophorectomy.
BMI, body mass index; FIGO, International Federation of Gynecology and Obstetrics ; HGNECC, high-grade neuroendocrine cervical carcinoma .