Table 4

Overview of literature on fertility and reproductive outcomes after gestational trophoblastic neoplasia treated with single agent or multi-agent chemotherapy

ReferenceChemotherapyWomen with pregnancy wish
n
Pregnant women nTotal pregnancies nOutcome of pregnancies
Miscarriage
n (%)
TOP
n (%)
Ectopic
n (%)
Live birth
n (%)
Preterm birth
n (%)
Stillbirth
n (%)
Cong abn
n (%)
Repeat mole
n (%)
Ross55 Single agent n=88
Multi-agent n=18
10658
49
7
9615 (15.6)NDND78 (81.3)ND3 (3.1)3 (3.1)ND
Hsieh et al62 MTX or ACT-D
MTX/ACT-D/CP
ND11132 (15.4)NDND10 (76.9)NDND1 (7.7)ND
Song et al63 Single agent (6-MP, 5-FU, KSM, MTX) n=91
Multi-agent n=107
ND20535526 (7.3)23 (6.5)2 (0.6)303 (85.4)20 (5.6)3 (0.8)3 (0.8)2 (0.6)
Ngan et al64 Etoposide
MTX
ACT-D
Multi-agent
41ND416 (14.6)2 (4.9)0 (0)32 (78)1 (2.4)0 (0)ND0 (0)
Kjer et al65 MTX/VC/ACT-D/CP
MTX/ACT-D
3029626 (9.7)ND1 (1.6)NDNDNDND1 (1.6)
Ayhan et al66 CHM prophylaxis MTX n=43
MTX n=2
MX/ACT-D n=3
MTX/ACT-D/CP n=1
ND49658 (12.3)7 (10.8)ND42 (64.6)4 (6.2)1 (1.5)0 (0)3 (4.6)
Kim et al16 NDND38509 (18)ND1 (2)33 (66)4 (8)0 (0)1 (2)3 (6)
Woolas et al35 Single agent n=396
Multi-agent n=336
728680NDNDNDND1000NDNDND18 ()
Amr et al67 MTX
EMA/CO
MAC
55421207 (5.8)ND1 (0.8)94 (78.3)15 (12.5)3 (2.5)2 (1.7)ND
Braga et al41  MTX or ACT-D n=167
 EMA/CO, MAC, CHAMOCA, EP/EMA n=85
 NDND25242
(16.7)
NDND172
(68.3)
6
(2.4)
2
(0.8)
6 (2.4) 7 (2.8)
Vargas et al20 NDNDND667123 (18.4)28 (4.2)7 (1)446 (66.9)44 (6.6)10 (1.5)12 (1.8)9 (1.3)
Williams et al56 MTX or ACT-D n=745
EMA/CO n=459
ND24425533 (12.9)25 (9.8)5 (2)187 (73.3)14 (5.5)1 (0.4)ND4 (1.6)
Matsui et al42 MTX or ACT-D or ETO n=295
MEA or MAC n=83
13312924327 (11.1)35 (14.4)ND169 (69.5%)2 (0.8)5 (2.1)ND5 (2.1)
  • Cong abn, congenital abnormalities; ACT-D, actinomycin D; CHAMOCA, cyclophosphamide, hydroxyurea, actinomycin D, methotrexate, doxorubicin, melphalan, vincristine ; CHM, complete hydatidiform mole; CP, cyclophosphamide; EMA/CO, etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine; EP/EMA, etoposide, cisplatin, etoposide methotrexate, actinomycin D; 5-FU, 5-fluorouracil; KSM, kasugamycin, strain of streptomycetes; MAC, methotrexate, actinomycin D, chlorambucil; MEA, methotrexate, etoposide, actinomycin D; 6-MP, 6-mercaptopurine; MTX, methotrexate; ND, not described; TOP, termination of pregnancy; VC, vincristine.