Table 2

Overview of literature on fertility and reproductive outcomes after gestational trophoblastic neoplasia treated with single-agent chemotherapy

ReferenceChemotherapyNumber of patients with pregnancy wish
n
Number of pregnant women
n
Number of pregnancies
n
Outcome of pregnancies
Miscarriage
n (%)
TOP
n (%)
Ectopic
n (%)
Live birth
n (%)
Preterm birth
n (%)
Stillbirth
n (%)
Cong abn
n (%)
Repeat mole
n (%)
Woolas et al35 MTX354392ND38 (9.9)NDNDNDNDNDNDND
Blagden et al,36 MTXND15315312 (8)NDND120 (78)ND2 (0.9)1 (0.7)2 (1.3)
Khan et al,37 MTXND14116121 (13.0)NDND128 (79.5)ND0 (0)NDND
Matsui et al38 MTX
ACT-D
ETO
ND8739
14
34
ND6 (15.4)
0
0
ND29 (74.4)
12 (85.7)
27 (79.4)
NDNDNDND
Goto et al39 MTX
ACT-D
ND20944657 (12.8)33 (7.4)6 (1.3)339 (76)9 (2)0 (0)3 (0.7)5 (1.1)
Wong et al32 MTX1297217 (23.6)NDND55 (76.4)ND0 (0)1 (1.4)0
Williams et al56 MTX
ACT-D
ND17018229 (15.9)17 (9.3)4 (2.2)130 (71.4)8 (4.4)0 (0)ND2 (1.1)
Cioffi et al31 MTX, n=42
ACT-D, n=2
ETO, n=1
4224327 (21.9)ND0 (0)25 (78.1)ND0 (0)(0)ND
  • Cong abn, congenital abnormalities; ACT-D, actinomycin D; EtO, etoposide; MTX, methotrexate; ND, not described; TOP, termination of pregnancy.