Overview of literature on fertility and reproductive outcomes after gestational trophoblastic neoplasia treated with single-agent chemotherapy
| Reference | Chemotherapy | Number of patients with pregnancy wish n | Number of pregnant women n | Number of pregnancies n | Outcome of pregnancies | |||||||
| Miscarriage n (%) | TOP n (%) | Ectopic n (%) | Live birth n (%) | Preterm birth n (%) | Stillbirth n (%) | Cong abn n (%) | Repeat mole n (%) | |||||
| Woolas et al35 | MTX | 354 | 392 | ND | 38 (9.9) | ND | ND | ND | ND | ND | ND | ND |
| Blagden et al,36 | MTX | ND | 153 | 153 | 12 (8) | ND | ND | 120 (78) | ND | 2 (0.9) | 1 (0.7) | 2 (1.3) |
| Khan et al,37 | MTX | ND | 141 | 161 | 21 (13.0) | ND | ND | 128 (79.5) | ND | 0 (0) | ND | ND |
| Matsui et al38 | MTX ACT-D ETO | ND | 87 | 39 14 34 | ND | 6 (15.4) 0 0 | ND | 29 (74.4) 12 (85.7) 27 (79.4) | ND | ND | ND | ND |
| Goto et al39 | MTX ACT-D | ND | 209 | 446 | 57 (12.8) | 33 (7.4) | 6 (1.3) | 339 (76) | 9 (2) | 0 (0) | 3 (0.7) | 5 (1.1) |
| Wong et al32 | MTX | 1 | 29 | 72 | 17 (23.6) | ND | ND | 55 (76.4) | ND | 0 (0) | 1 (1.4) | 0 |
| Williams et al56 | MTX ACT-D | ND | 170 | 182 | 29 (15.9) | 17 (9.3) | 4 (2.2) | 130 (71.4) | 8 (4.4) | 0 (0) | ND | 2 (1.1) |
| Cioffi et al31 | MTX, n=42 ACT-D, n=2 ETO, n=1 | 42 | 24 | 32 | 7 (21.9) | ND | 0 (0) | 25 (78.1) | ND | 0 (0) | (0) | ND |
Cong abn, congenital abnormalities; ACT-D, actinomycin D; EtO, etoposide; MTX, methotrexate; ND, not described; TOP, termination of pregnancy.