Ovarian function and fertility preservation
| Fertility preservation | Median age (years) | Sample | Cancer | Total dose of gonadotropins | No of oocytes retrieved | No of oocytes cryopreserved | |||||||||||||||||||||||||
| Article | Year | Type of study | No of patients | BRCA mutated | BRCA 1 | BRCA 2 | BRCA WT | Other | BRCA mutated | BRCA 1 | BRCA 2 | BRCA WT | Other | Breast cancer | Other cancer | No cancer | BRCA mutated | BRCA 1 | BRCA 2 | BRCA WT | Other | BRCA mutated | BRCA 1 | BRCA 2 | BRCA WT | Other | BRCA mutated | BRCA 1 | BRCA 2 | BRCA WT | Other |
| Porcu et al17 | 2020 | Prospective study | 227 | 32.3 | 31.5 | 33.2 | 32.5 | 32.4 | 22 | 11 | 11 | 24 | 181 | 46 | 0 | 181 | 2126 | 2206 | 2047.5 | 2106.3 | 1597 | 8.35 | 6.7 | 10 | 9.1 | 8.8 | 5.35 | 3.1 | 7.6 | 7.2 | 7.3 |
| Grynberg et al | 2019 | Retrospective study | 329 | 31.7 | / | / | 32.3 | / | 52 | 36 | 16 | 277 | 0 | 329 | 0 | 0 | / | / | / | / | / | 8.9 | 9.1 | 8.1 | 9.9 | / | 5.1 | 4.9 | 5.4 | 6.1 | / |
| Gunnala et al | 2019 | Retrospective study | 795 | 32.4 | / | / | 35.5 | / | 57 | 31 | 18 | 738 | 8* | 91 | 0 | 619 | 3166.4 | 2958.8 | 3283.3 | 3329 | / | 16.6 | 15.5 | 17.1 | 13.5 | / | 14.0 | 13.5 | 14.2 | 10.4 | / |
| Lambertini et al | 2018 | Retrospective study | 156 | 31 | / | / | 31 | / | 29 | 19 | 10 | 72 | 55* | 156 | 0 | 0 | 2775 | 2775 | 2775 | 2025 | / | 6.5 | 7 | 6 | 9 | / | 3.5 | 5 | 3 | 6 | / |
| Derks-Smeets et al | 2017 | Retrospective study | 217 | 31.4 | / | / | 32.1 | / | 43 | 20 | 23 | 174 | 0 | 0 | 0 | 0 | 1987.5 | 1950 | 2137.5 | 1950 | / | 7 | 6.5 | 7.5 | 8.0 | / | / | / | / | / | / |
| Shapira et al | 2015 | Retrospective study | 124 | 31.92 | / | / | 32.09 | / | 62 | 43 | 17 | 62 | 1* | 42 | 0 | 82 | 2482 | / | / | 2658 | / | 13.75 | / | / | 14.75 | / | / | / | / | / | / |
*unknown.
WT, wild-type.