Table 5

Overview of literature on fertility and reproductive outcomes after placental site and epithelioid trophoblastic tumor

AuthorMethodPatientsFertility-sparing treatmentType of fertility-sparing procedureMaternal outcomesFertility outcomes
Bonazzi et al92 Retrospective cohortPSTT n=1Hysteroscopic resection n=1NDND
Zhang et al83 Literature reviewPSTT n=2ChemotherapyNDND
Taylor et al93 Case reportPSTT n=1Hysteroscopic resectionNDSalvage hysterectomy
Imamura et al98
2015		Case reportETT n=1Laparotomic resectionAdditional chemotherapy
No recurrence		ND
Renaud et al96
2015		Case reportPSTT n=2D&CNDSalvage hysterectomy
Tse et al97 Case reportETT n=1Laparotomic resectionNDLive birth n=2
Zhao et al79 PSTT n=23Chemotherapy n=20Death n=1
Partial response n=1		Live birth n=7
(which group?)
Laparotomic resection n=2NDND
D&C n=1NDND
Chiofalo et al84 Systematic review
nine studies		PSTT n=18Open procedure n=11Laparotomic resection n=7Additional chemotherapy n=3Salvage hysterectomy n=5
Modified Strassman procedure n=4NDND
Minimally invasive approach n=6D&C
Hysteroscopic resection		NDND
Chemotherapy only n=1NDLive birth n=1
Zhang et al95 Literature review and case reportPSTT n=42
ETT n=19
Mixed PSTT/ETT n=1		Local resection n=10Additional chemotherapy n=10
No recurrence n=7
ND n=3		Live birth n=2
Alexander et al94 Case reportPSTT n=13Hysteroscopic resection n=1No recurrenceND

  • PSTT, placental site trophoblastic tumor; ETT, epithelioid trophoblastic tumor; ND, not described; Min invasive approach, minimally invasive approach