Comparison of clinicopathological features between patients with villoglandular adenocarcinoma and those with standard cervical adenocarcinoma*
| Villoglandular adenocarcinoma (n=47) | Standard adenocarcinoma (n=104) | P value | |
| Median age±SD | 43.8±7.6 | 47.1±8.9 | 0.029* |
| BMI, kg/m2 | 22.2±2.9 | 23.0±2.8 | 0.22 |
| Menopause | 33 | 104 | <0.001* |
| Yes | 27/33 (81.8) | 69 (66.3) | |
| No | 6/33 (18.2) | 35 (33.7) | |
| FIGO stage (2009) | 0.001* | ||
| IA1 | 0 | 13 (12.5) | |
| IA2 | 4 (8.5) | 5 (4.8) | |
| IB1 | 35 (74.5) | 83 (79.8) | |
| IB2 | 8 (17.0) | 3 (2.9) | |
| Surgery | 0.79 | ||
| Radical hysterectomy | 42 (89.4) | 90 (86.5) | |
| Simple hysterectomy | 5 (10.6) | 14 (13.5) | |
| Adjuvant therapy | |||
| Yes | 28 (59.6) | 64 (61.5) | 0.86 |
| No | 19 (40.4) | 40 (38.5) | |
| Grade | 0.003* | ||
| Ⅰ | 13/28 (46.4) | 10/57 (17.5) | |
| Ⅱ | 14/28 (50.0) | 28 (49.1) | |
| Ⅲ | 1/28 (3.6) | 19 (33.3) | |
| Tumor size (mean±SD) | 3.0±1.3 | 2.6±1.3 | 0.20 |
| <2 cm | 14 (29.8) | 49/101 (48.5) | |
| 2–4 cm | 21 (44.7) | 41/106 (40.6) | |
| ≥4 cm | 12 (25.5) | 11/106 (10.9) | |
| Depth of cervical interstitial infiltration | 0.004* | ||
| ≤1/2 | 28/40 (70.0) | 40/60 (66.7) | |
| >1/2 | 12/40 (30.0) | 20/60 (33.3) | |
| Lymphovascular invasion | 0.37 | ||
| Yes | 2/36 (5.6) | 11/75 (14.7) | |
| No | 34/36 (94.4) | 64/75 (85.3) | |
| Uterine infiltration | 0.32 | ||
| Yes | 3 (6.4) | 5 (4.8) | |
| No | 44 (93.6) | 99 (95.2) | |
| Parametrium invasion | 1.00 | ||
| Yes | 0 | 1 (1.0) | |
| No | 47 (100.0) | 103 (99.0) | |
| Lymph node metastasis | 0.72 | ||
| Yes | 2/40 (5.0) | 8/90 (8.9) | |
| No | 38/40 (95.0) | 82/90 (91.1) | |
| Recurrence | 0 | 6 | |
| Median relapse-free survival ±SD (months) | 60.5±36.0 | 33.4±25.4 | <0.001* |
| Death | 0 | 3 | |
| Median survival time ±SD (months) | 60.5±36.0 | 34.5±25.6 | ＜0.001* |
*Results are number (%) unless stated otherwise
BMI, body mass index; SD, standard deviation.