χ2 association analysis between clinico-pathologic parameters in 464 FIGO stage IB invasive endocervical adenocarcinomas (contingency table, χ2)
| Parameter | FIGO stage IB1 | FIGO stage IB2 | FIGO stage IB3 | P value |
| n (%) | n (%) | n (%) | ||
| No (%) of patients | 225 (48) | 177 (38) | 62 (13) | |
| Mean age (median), years | 43.7 (41) | 46.1 (43.7) | 49.1 (46) | 0.005* |
| SD, ICQ25–75 | 10.670 (36–50) | 13.294 (36–54.5) | 13.546 (40–58) | |
| <50 years | 167 (74) | 115 (65) | 35 (57) | 0.014 |
| ≥50 years | 58 (26) | 62 (35) | 27 (43) | |
| Surgical treatment | 0.002 | |||
| Conization | 24 (11) | 3 (2) | 2 (3) | |
| Trachelectomy | 11 (5) | 10 (6) | – | |
| Hysterectomy | 190 (84) | 164 (93) | 60 (97) | |
| Precursor lesions | 0.00001 | |||
| Present | 131 (58) | 95 (54) | 19 (31) | |
| Absent | 53 (24) | 55 (31) | 29 (47) | |
| N/A | 41 (18) | 27 (15) | 14 (23) | |
| HPV status | 0.00001 | |||
| Positive | 175 (78) | 123 (69) | 31 (50) | |
| Negative | 12 (5) | 22 (12) | 18 (29) | |
| N/A | 38 (17) | 32 (18) | 13 (21) | |
| Silva pattern | 0.00001 | |||
| A | 35 (16) | 20 (11) | 2 (3) | |
| B | 44 (20) | 21 (12) | 3 (5) | |
| C | 106 (47) | 114 (64) | 43 (69) | |
| N/A | 40 (18) | 22 (12) | 14 (23) | |
| Tumor grade | 0.00001 | |||
| G1 | 73 (32) | 38 (21) | 5 (8) | |
| G2 | 126 (56) | 104 (59) | 32 (52) | |
| G3 | 24 (11) | 28 (16) | 21 (34) | |
| N/A | 2 (1) | 7 (4) | 4 (6) | |
| Lymphovascular invasion | 0.00001 | |||
| Positive | 65 (29) | 86 (49) | 47 (76) | |
| Negative | 142 (63) | 81 (46) | 13 (21) | |
| N/A | 18 (8) | 10 (6) | 2 (3) | |
| Regional/remote lymph node metastasis | 0.002 | |||
| Positive | 12 (5) | 18 (10) | 12 (19) | |
| Negative | 186 (83) | 142 (80) | 43 (69) | |
| N/A | 27 (12) | 17 (10) | 7 (11) | |
| Recurrence | 0.001 | |||
| Yes | 21 (9) | 28 (16) | 17 (27) | |
| No | 177 (79) | 124 (70) | 39 (63) | |
| N/A | 27 (12) | 25 (14) | 6 (10) | |
| Local recurrence | 0.06 | |||
| Yes | 15 (7) | 13 (7) | 10 (16) | |
| No | 183 (81) | 139 (79) | 46 (74) | |
| N/A | 27 (12) | 25 (14) | 6 (10) | |
| Distant recurrence | 0.009 | |||
| Yes | 6 (3) | 15 (8) | 7 (11) | |
| No | 192 (85) | 137 (77) | 49 (79) | |
| N/A | 27 (12) | 25 (14) | 6 (10) |
Bold type indicates statistical significance.
*ANOVA test.
FIGO, International Federation of Gynecology and Obstetrics; HPV, human papillomavirus.