Table 2

Studies noted by the International Agency for Research of Cancer 2012 Working Group as primarily establishing a causal connection between asbestos occupational exposure and ovarian cancer21

StudyYearStudy summaryPathology reviewedComment
Acheson et al70 1982Cohort study, two groups, 757 women exposed to crocodolite fibers (SMR 2.75, 95% CI 1.42 to 4.81) and 570 exposed to chrysotile (SMR 1.48, 95% CI 0.48 to 3.44)NoneNone
Wignall and Fox71 1982Cohort study, 500 women with crocodolite exposure (SMR 2.13, p<0.01)3/500 samples reviewed. 1/3 ovarian cancer (33%) misdiagnosed, 1 was malignant mesotheliomaUnknown preparation and whether immunostains used prior to 1982 publication date. PAX-8 immunostaining not available at time of publication
Berry et al75 2000Cohort study, 700 women exposed to multiple fiber types (SMR 2.53, 95% CI 1.16 to 4.80)6/700 samples reviewed. 2/6 ovarian cancer (33%) misdiagnosed, unknown other pathologyPathology reviewed in prior papers, either in 196976 or 1985,77 unknown stains used prior to 1969 or 1985. PAX-8 immunostaining not available at time of publication
Germani et al72 1999Cohort study, 631 women from registry of women exposed to any fiber type of asbestos (SMR 4.77, 95% CI 2.1 to 9.06)NoneNone
Magnani et al73 2008Cohort study, 777 women exposed to mixed fibers (SMR 2.27, p<0.05)9/777 samples reviewed, 2/9 ovarian cancer cases misdiagnosed (22%), unknown other pathologyUnknown if this was pathologic review or by report. Unknown year or immunostains. PAX-8 immunostaining likely not available at time of publication
  • SMR, standardized mortality ratio.