Table 3

Post-operative major complications

CharacteristicOverall
(n=158)
Arm A
PDS
(n=84)
Arm B
NACT-IDS
(n=74)
P value
N (%)N (%)N (%)
Early (≤30 days)
 Patients with major complications46 (29.1)39 (46.4)7 (9.5) <0.0001
 All events269 (100)177 (65.8)92 (34.2)
 Major events53 (19.7)46 (25.9)7 (7.6) <0.0001*
 Grade III47 (17.5)40 (22.6)7 (7.6) 0.002
 Grade IV3 (1.1)3 (1.7)0 (0)0.209
 Grade V3 (1.1)3 (1.7)0 (0)0.2019
Late (1–6 months)
 Patients with major complications11 (7.0)10 (11.9)1 (1.4) 0.009
 All events35 (100)31 (88.6)4 (11.4)
 Major events14 (40.0)13 (41.9)1 (25.0)0.515*
 Grade III7 (20.0)6 (19.3)1 (25.0)0.791
 Grade IV3 (8.6)3 (9.7)0 (0)0.588
 Grade V4 (11.4)4 (12.9)0 (0)0.455
  • Bold font highlights statistically significant differences.

  • Rates are calculated on all events.

  • *Major (grades 3, 4, and 5) versus minor (grades 1 and 2) complications.10

  • IDS, interval debulking surgery; NACT, neoadjuvant chemotherapy; PDS, primary debulking surgery.