Table 2

Operative details for debulked patients

CharacteristicOverall
(n=158)
Arm A
PDS
(n=84)
Arm B
NACT-IDS
(n=74)
P value
N (%)N (%)N (%)
Size of residual disease 0.001
 No gross97 (61.4)40 (47.6)57 (77.0)
 1 −10 mm54 (34.2)38 (45.2)16 (21.6)
  Reasons
   Miliary carcinomatosis43 (27.2)27 (32.1)16 (21.6)
   Hepatic hilum6 (3.8)6 (7.1)0 (0)
   Retroperitoneal disease5 (3.2)5 (6.0)0 (0)
 >10 mm7 (4.4)6 (7.1)1 (1.4)
  Reasons
   Miliary carcinomatosis0 (0)0 (0)0 (0)
   Hepatic hilum4 (2.5)4 (4.8)0 (0)
   Retroperitoneal disease2 (1.3)2 (2.4)0 (0)
   Abdominal disease1 (0.6)0 (0)1 (1.4)
   No cytoreducion for progressive disease13/171 (7.6)0/84 (0)13/87 (14.9)
Surgical complexity score9 <0.0001
 143 (27.2)0 (0)43 (58.1)
 229 (18.4)9 (10.7)20 (27.0)
 386 (54.4)75 (89.3)11 (14.9)
Upper abdominal procedures <0.0001
 Yes111 (70.3)83 (98.8)28 (37.8)
 No47 (29.7)1 (1.2)*46 (62.2)
Operative time (min), mean (SD)363.5 (145.3)460.6 (102.6)253.2 (101.4) <0.0001
IO complications6 (3.8)4 (4.8)2 (2.7)0.518
 Vascular3 (1.9)3 (3.6)0 (0)
 Biliary duct1 (0.6)1 (1.2)0 (0)
 PTX after lung resection1 (0.6)0 (0)1 (1.4)
 Bladder injury1 (0.6)0 (0)1 (1.4)
Mean hospital stay (days) (SD)11 (9.5)14.8 (11.3)6.7 (3.9) <0.0001
  • Bold font highlights statistically significant differences.

  • *One patient did not undergo upper abdominal procedures because deemed unresectable at laparotomy.

  • IDS, interval debulking surgery; IO, intra-operative; NACT, neoadjuvant chemotherapy; PDS, primary debulking surgery; PTX, pneumothorax.