Characteristic | Overall (n=158) | Arm A PDS (n=84) | Arm B NACT-IDS (n=74) | P value |
N (%) | N (%) | N (%) | ||
Size of residual disease | 0.001 | |||
No gross | 97 (61.4) | 40 (47.6) | 57 (77.0) | |
1 −10 mm | 54 (34.2) | 38 (45.2) | 16 (21.6) | |
Reasons | ||||
Miliary carcinomatosis | 43 (27.2) | 27 (32.1) | 16 (21.6) | |
Hepatic hilum | 6 (3.8) | 6 (7.1) | 0 (0) | |
Retroperitoneal disease | 5 (3.2) | 5 (6.0) | 0 (0) | |
>10 mm | 7 (4.4) | 6 (7.1) | 1 (1.4) | |
Reasons | ||||
Miliary carcinomatosis | 0 (0) | 0 (0) | 0 (0) | |
Hepatic hilum | 4 (2.5) | 4 (4.8) | 0 (0) | |
Retroperitoneal disease | 2 (1.3) | 2 (2.4) | 0 (0) | |
Abdominal disease | 1 (0.6) | 0 (0) | 1 (1.4) | |
No cytoreducion for progressive disease | 13/171 (7.6) | 0/84 (0) | 13/87 (14.9) | |
Surgical complexity score9 | <0.0001 | |||
1 | 43 (27.2) | 0 (0) | 43 (58.1) | |
2 | 29 (18.4) | 9 (10.7) | 20 (27.0) | |
3 | 86 (54.4) | 75 (89.3) | 11 (14.9) | |
Upper abdominal procedures | <0.0001 | |||
Yes | 111 (70.3) | 83 (98.8) | 28 (37.8) | |
No | 47 (29.7) | 1 (1.2)* | 46 (62.2) | |
Operative time (min), mean (SD) | 363.5 (145.3) | 460.6 (102.6) | 253.2 (101.4) | <0.0001 |
IO complications | 6 (3.8) | 4 (4.8) | 2 (2.7) | 0.518 |
Vascular | 3 (1.9) | 3 (3.6) | 0 (0) | |
Biliary duct | 1 (0.6) | 1 (1.2) | 0 (0) | |
PTX after lung resection | 1 (0.6) | 0 (0) | 1 (1.4) | |
Bladder injury | 1 (0.6) | 0 (0) | 1 (1.4) | |
Mean hospital stay (days) (SD) | 11 (9.5) | 14.8 (11.3) | 6.7 (3.9) | <0.0001 |
Bold font highlights statistically significant differences.
*One patient did not undergo upper abdominal procedures because deemed unresectable at laparotomy.
IDS, interval debulking surgery; IO, intra-operative; NACT, neoadjuvant chemotherapy; PDS, primary debulking surgery; PTX, pneumothorax.