Demographics, pathology, and recurrence characterization (analysis groups)
| Factor | Data available | OBS | EBRT | VBT | VBT+C | P value |
| (n=101) | (n=46) | (n=138) | (n=58) | |||
| Demographics | ||||||
| Age of diagnosis (years) | 342 | 67.8±11.9 | 67.7±8.8 | 67.9±9.5 | 64.3±7.2 | 0.11a |
| BMI (kg/m2) | 313 | 32.3±9.1 | 31.9±9.5 | 31.9±8.5 | 32.9±8.7 | 0.90a |
| Race | 343 | |||||
| Caucasian | 89 (88.1) | 42 (91.3) | 120 (87.0) | 56 (96.6) | ||
| Black | 5 (5.0) | 2 (4.3) | 12 (8.7) | 2 (3.4) | ||
| Asian | 0 (0.0) | 0 (0.00) | 2 (1.4) | 0 (0.00) | ||
| Hispanic | 1 (1.0) | 1 (2.2) | 0 (0.0) | 0 (0.00) | ||
| Other | 4 (4.0) | 1 (2.2) | 1 (0.72) | 0 (0.00) | ||
| Gravida | 294 | 2.0 (1.00 to 3.0) | 2.0 (1.00 to 3.0) | 2.0 (1.00 to 3.0) | 2.0 (1.00 to 3.0) | 0.76b |
| Parity | 323 | 2.0 (1.00 to 3.0) | 2.0 (1.00 to 2.0) | 2.0 (1.00 to 3.0) | 2.0 (1.00 to 3.0) | 0.51b |
| Menarche | 165 | 12.6±1.6 | 12.5±1.6 | 12.4±1.6 | 12.8±1.6 | 0.64a |
| Menopause | 340 | 0.26c | ||||
| Pre-menopause | 13 (12.9) | 4 (8.9) | 11 (8.1) | 10 (17.2) | ||
| Post-menopause | 88 (87.1) | 41 (91.1) | 125 (91.9) | 48 (82.8) | ||
| Pathology | ||||||
| Endometrial stripe (mm) | 124 | 18 (11.0 to 23.0) | 15 (9.9 to 30.0) | 17.5 (11.5 to 24.7) | 16 (7.5 to 22.5) | 0.70b |
| Surgical approach | 343 | <0.001 c | ||||
| Laparotomy | 28 (27.7)*† | 4 (8.7) | 19 (13.8)‡ | 4 (6.9)‡ | ||
| Laparoscopic | 34 (33.7) | 18 (39.1) | 32 (23.2) | 14 (24.1) | ||
| Robotic | 30 (29.7) | 23 (50.0) | 78 (56.5) | 39 (67.2) | ||
| Vaginal | 9 (8.9) | 1 (2.2) | 9 (6.5) | 1 (1.7) | ||
| BSO performed | 321 | 90 (95.7) | 45 (97.8) | 123 (98.4) | 56 (100.0) | 0.41d |
| Washing | 340 | 0.039c | ||||
| Positive | 6 (6.1) | 7 (15.2) | 5 (3.6) | 3 (5.2) | ||
| Atypical | 3 (3.1) | 4 (8.7) | 5 (3.6) | 1 (1.7) | ||
| Negative | 49 (50.0) | 25 (54.3)† | 74 (53.6)§ | 25 (43.1) | ||
| Lymphadenectomy performed¶ | 342 | 63 (63.0)*† | 35 (76.1) | 114 (82.6)‡ | 50 (86.2)‡ | 0.001c |
| Pelvic (number of nodes obtained) | 260 | 17 (12 to 24)§ | 11 (7 to 17)*‡ | 20 (13 to 27)§ | 14 (11 to 23) | <0.001b |
| Para-aortic (number of nodes obtained) | 215 | 7 (2 to 13) | 3.5 (0 to 7)† | 8.5 (3 to 14)§ | 4.0 (0 to 10) | 0.002b |
| Sentinel node biopsy performed¶ | 327 | 6 (6.3) | 1 (2.3) | 13 (9.7) | 4 (7.3) | 0.42c |
| Stage (FIGO 2009) | 343 | 0.003c | ||||
| IA | 45 (44.6)†§ | 8 (17.4)‡ | 57 (41.3) | 13 (22.4)‡ | ||
| IB | 50 (49.5) | 33 (71.7) | 71 (51.4) | 35 (60.3) | ||
| II | 6 (5.9) | 5 (10.9) | 10 (7.2) | 10 (17.2) | ||
| Final grade | 343 | 0.070c | ||||
| 1 | 23 (22.8) | 7 (15.2) | 19 (13.8) | 6 (10.3) | ||
| 2 | 54 (53.5) | 29 (63.0) | 78 (56.5) | 27 (46.6) | ||
| 3 | 24 (23.8) | 10 (21.7) | 41 (29.7) | 25 (43.1) | ||
| Histology | 343 | 0.32d | ||||
| Endometrioid | 101 (100.0) | 45 (97.8) | 137 (99.3) | 57 (98.3) | ||
| Non-endometrioid | 0 (0.00) | 1 (2.2) | 1 (0.72) | 1 (1.7) | ||
| Myometrial invasion (%) | 309 | 0.65 (0.31 to 0.75) | 0.60 (0.50 to 0.80) | 0.54 (0.33 to 0.75) | 0.59 (0.43 to 0.76) | 0.34b |
| Tumor size (cm) | 298 | 4.7±2.7 | 4.5±2.1 | 4.0±2.0 | 4.6±2.1 | 0.12a |
| Lower uterine segment | 199 | 13 (28.9) | 7 (33.3) | 13 (14.8)† | 17 (37.8)* | 0.019c |
| Survival | ||||||
| Length of follow-up (months) | 343 | 35.9 (19.8, 68.6)† | 38.4 (24.7 to 68.3) | 42.8 (27.8 to 65.8) | 54.1 (43.2 to 75.7)‡ | 0.009b |
| Location of recurrence | 343 | 0.15c | ||||
| Vaginal | 9 (8.9) | 0 (0.00) | 4 (2.9) | 2 (3.4) | ||
| Local (pelvic) | 4 (4.0) | 0 (0.00) | 1 (0.72) | 3 (5.2) | ||
| Distant | 9 (8.9) | 6 (13.0) | 12 (8.7) | 4 (6.9) | ||
| Multi-site | 5 (5.0) | 3 (6.5) | 5 (3.6) | 1 (1.7) |
Statistics presented as mean±SD, median (25th to 75th centile), N (column %).
Post-hoc pairwise comparisons where done using Bonferroni adjustment.
P values: a=analysis of variance, b=Kruskal-Wallis test, c=Pearson's chi-square test, d=Fisher's exact test.
Race unknown: OBS = 2, VBT = 3.
*Significantly different from VBT.
†Significantly different from VBT+chemo.
‡Significantly different from observation.
§Significantly different from EBRT.
¶All lymph nodes were negative for malignancy.
BMI, body mass index; BSO, bilateral salpingo-oophorectomy; C, chemotherapy; EBRT, external beam radiation therapy; FIGO, International Federation of Gynecology and Obstetrics; OBS, observation; VBT, vaginal brachytherapy.