Table 3

Summary of 12 patients with suspected lobular endocervical glandular hyperplasia who underwent hysterectomy after follow-up

Case NoAge (years)Reason for operationReasons for s/o maligMRI findingsGrowth rate (%)Cytology‘Yellow/orange’ mucinHIK1083 testCervical biopsy /conizationMode of surgeryPathological diagnosis, stageF/U period (months)State at last F/U
2950s/o maligIncreased size, worsening cytologyCP38.1AGC-NOS→AGC-FN++s/o Adenoca/MDARH, BSO, PLN, OMMDA, IIB58NED
3055s/o maligIncreased sizeCP87.5AGC-NOS++NA/NATAH, BSOLEGH with atypia3NED
3133s/o maligIncreased sizeCP148NILM→AGC-NOS- → +- → +NA/LEGH with atypiaTAH, BSOLEGH with atypia154NED
3249s/o maligIncreased size, DRCP29.1AGC-NOS++NA/LEGHTAH, BSOLEGH31NED
3349s/o maligIncreased sizeCP33.3AGC-NOS++NA/NATLH, BSOLEGH51NED
3441s/o maligIncreased size, IPCP45AGC-NOS++No malig/NATLHLEGH61NED
3539s/o maligIncreased sizeCP42.9AGC-NOS++LEGH/NATAHLEGH68NED
3636s/o maligIncreased size, DR, worsening cytologyCP28.5AGC-NOS→AGC-FN++NA/LEGHTAHLEGH91NED
3734s/o maligIncreased size, SPCP100AGC-NOS++NA/NATLHLEGH47NED
3833s/o maligWorsening cytologyCP−14.3AGC-NOS→AGC-FN+NA/NATAH, BSO, OMLEGH25Died of OvCa
3937Other disease*CP−29.2AGC-NOS++No malig/LEGHTLH, BSOLEGH96NED
4035Other disease†CP−31.8AGC-NOS++NA/NATLHLEGH72NED
  • *Atypical endometrial hyperplasia.

  • †Adenomyosis.

  • AGC-FN, atypical glandular cells-favor neoplastic; AGC-NOS, atypical glandular cells-not otherwise specified; BSO, bilateral salpingo-oophorectomy; ca, carcinoma; CP, cosmos pattern; DR, diffusion restriction; F/U, follow-up; IP, invasion pattern; LEGH, lobular endocervical glandular hyperplasia; MDA, minimal deviation adenocarcinoma; MRI, magnetic resonance image; NA, not available; NED, no evidence of disease; NILM, negative for intraepithelial lesion or malignancy; No malig, no malignancy; OM, omentectomy; OvCa, ovarian cancer; PLN, pelvic lymphadenectomy; RH, radical hysterectomy; sLEGH, suspected lobular endocervical glandular hyperplasia; s/o Adenoca, suspicious of adenocarcinoma; s/o malig, suspicious of malignancy; SP, solid pattern; TAH, total abdominal hysterectomy; TLH, total laparoscopic hysterectomy.