Table 1

Univariate analysis of predictive factors associated with parametrial involvement

Predictive variableTotal population
n=174
Group with parametrial involvement
n=9
P value
n, mean±SD%(range)n, mean±SD%(range)
Age (years)
 Mean43.3±11.8(22–81)44.6±13.3(31–77)0.75
 <5013275.986.10.15
 50–703620.700.0
 ≥7063.4116.7
BMI (kg/m2)
 Mean23.5±5.0(14.6–41.4)26.5±6.0(19.8–38.8)0.07
 <18.5148.000.00.69
 18.5–2511767.265.1
 ≤25–302112.114.8
 ≥302212.629.1
Clinical FIGO stage
 IA1 with emboli–IA22011.500.00.67
 IB19454.066.4
 IB25732.835.3
 IIA131.700.0
Histology
 Squamous cell carcinoma11063.687.30.26
 Adenocarcinoma5632.411.8
 Other type74.000.0
 Not specified1
Grade of differentiation
 G15543.311.80.27
 G24636.248.7
 G32620.527.7
 Not specified472
Lymphovascular space invasion in biopsy or conization specimen
 Yes3724.738.10.39
 No11375.354.4
 Not specified241
Tumor size on pre-operative imaging
 Mean (mm)10.4±10.7(0–41)18.9±12.9(0–32)0.02
 Size <20 mm12773.021.60.0004
 Size ≥20 mm4727.0714.9
Conization
Pre-operative conization
 Yes10560.354.80.76
 No6939.745.8
Tumor size
 Mean (mm)13.6±7.4(1–35)20.8±4.3(15–27)0.02
 <20 mm74/10570.51/51.40.01
 ≥20 mm31/10529.54/512.9
Deep stromal invasion
 Mean (mm)7.1±5.8(1–35)11.0±4.6(6–15)0.23
 <10 mm70/10575.31/51.40.09
 ≥10 mm23/10524.72/58.7
 Not specified12/1052/5
Type of surgery
 Radical hysterectomy13275.986.10.35
 Radical trachelectomy4224.112.4
Type of lymph node staging
 SLN biopsy alone5531.611.80.17
 SLN biopsy + pelvic lymphadenectomy11968.486.7
SLN
 No of SLNs harvested3.9±1.8(2–10)3.3±1.9(2–7)0.33
Patients with positive SLNs
(frozen section)
 Yes53.5120.00.16
 No13796.575.1
 Frozen section not performed321
Patients with positive SLN
(ultrastaging)
 Yes2413.8520.80.0002
 No15086.242.7
SLN status
 Macrometastasis63.4233.30.001
 Micrometastasis95.2111.1
 Isolated tumor cells95.2222.2
 Negative15086.242.7
Final pathologic examination
Tumor size
 Mean (mm)10.5±12.1(0–60)29.4±11.9(15– 50)<0.0001
 <20 mm13076.021.50.0001
 ≥20 mm4124.0717.1
 Not specified3
Deep stromal invasion
 Mean (mm)5.8±7.8(0–40)17.8±8.8(6–30)<0.0001
 <10 mm11174.021.80.001
 ≥10 mm3926.0615.4
 Not specified241
Lymphovascular space invasion
 Yes6135.1711.50.006
 No11364.921.8
Vaginal invasion
 Yes116.4654.5<0.0001
 No16193.631.9
 Not specified2
Positive margin
 Yes95.2444.4<0.0001
 No16394.853.1
 Not specified2
  • FIGO, International Federation of Gynecology and Obstetrics; SLN, sentinel lymph node.