Univariate analysis of predictive factors associated with parametrial involvement
| Predictive variable | Total population n=174 | Group with parametrial involvement n=9 | P value | ||
| n, mean±SD | %(range) | n, mean±SD | %(range) | ||
| Age (years) | |||||
| Mean | 43.3±11.8 | (22–81) | 44.6±13.3 | (31–77) | 0.75 |
| <50 | 132 | 75.9 | 8 | 6.1 | 0.15 |
| 50–70 | 36 | 20.7 | 0 | 0.0 | |
| ≥70 | 6 | 3.4 | 1 | 16.7 | |
| BMI (kg/m2) | |||||
| Mean | 23.5±5.0 | (14.6–41.4) | 26.5±6.0 | (19.8–38.8) | 0.07 |
| <18.5 | 14 | 8.0 | 0 | 0.0 | 0.69 |
| 18.5–25 | 117 | 67.2 | 6 | 5.1 | |
| ≤25–30 | 21 | 12.1 | 1 | 4.8 | |
| ≥30 | 22 | 12.6 | 2 | 9.1 | |
| Clinical FIGO stage | |||||
| IA1 with emboli–IA2 | 20 | 11.5 | 0 | 0.0 | 0.67 |
| IB1 | 94 | 54.0 | 6 | 6.4 | |
| IB2 | 57 | 32.8 | 3 | 5.3 | |
| IIA1 | 3 | 1.7 | 0 | 0.0 | |
| Histology | |||||
| Squamous cell carcinoma | 110 | 63.6 | 8 | 7.3 | 0.26 |
| Adenocarcinoma | 56 | 32.4 | 1 | 1.8 | |
| Other type | 7 | 4.0 | 0 | 0.0 | |
| Not specified | 1 | ||||
| Grade of differentiation | |||||
| G1 | 55 | 43.3 | 1 | 1.8 | 0.27 |
| G2 | 46 | 36.2 | 4 | 8.7 | |
| G3 | 26 | 20.5 | 2 | 7.7 | |
| Not specified | 47 | 2 | |||
| Lymphovascular space invasion in biopsy or conization specimen | |||||
| Yes | 37 | 24.7 | 3 | 8.1 | 0.39 |
| No | 113 | 75.3 | 5 | 4.4 | |
| Not specified | 24 | 1 | |||
| Tumor size on pre-operative imaging | |||||
| Mean (mm) | 10.4±10.7 | (0–41) | 18.9±12.9 | (0–32) | 0.02 |
| Size <20 mm | 127 | 73.0 | 2 | 1.6 | 0.0004 |
| Size ≥20 mm | 47 | 27.0 | 7 | 14.9 | |
| Conization | |||||
| Pre-operative conization | |||||
| Yes | 105 | 60.3 | 5 | 4.8 | 0.76 |
| No | 69 | 39.7 | 4 | 5.8 | |
| Tumor size | |||||
| Mean (mm) | 13.6±7.4 | (1–35) | 20.8±4.3 | (15–27) | 0.02 |
| <20 mm | 74/105 | 70.5 | 1/5 | 1.4 | 0.01 |
| ≥20 mm | 31/105 | 29.5 | 4/5 | 12.9 | |
| Deep stromal invasion | |||||
| Mean (mm) | 7.1±5.8 | (1–35) | 11.0±4.6 | (6–15) | 0.23 |
| <10 mm | 70/105 | 75.3 | 1/5 | 1.4 | 0.09 |
| ≥10 mm | 23/105 | 24.7 | 2/5 | 8.7 | |
| Not specified | 12/105 | 2/5 | |||
| Type of surgery | |||||
| Radical hysterectomy | 132 | 75.9 | 8 | 6.1 | 0.35 |
| Radical trachelectomy | 42 | 24.1 | 1 | 2.4 | |
| Type of lymph node staging | |||||
| SLN biopsy alone | 55 | 31.6 | 1 | 1.8 | 0.17 |
| SLN biopsy + pelvic lymphadenectomy | 119 | 68.4 | 8 | 6.7 | |
| SLN | |||||
| No of SLNs harvested | 3.9±1.8 | (2–10) | 3.3±1.9 | (2–7) | 0.33 |
| Patients with positive SLNs (frozen section) | |||||
| Yes | 5 | 3.5 | 1 | 20.0 | 0.16 |
| No | 137 | 96.5 | 7 | 5.1 | |
| Frozen section not performed | 32 | 1 | |||
| Patients with positive SLN (ultrastaging) | |||||
| Yes | 24 | 13.8 | 5 | 20.8 | 0.0002 |
| No | 150 | 86.2 | 4 | 2.7 | |
| SLN status | |||||
| Macrometastasis | 6 | 3.4 | 2 | 33.3 | 0.001 |
| Micrometastasis | 9 | 5.2 | 1 | 11.1 | |
| Isolated tumor cells | 9 | 5.2 | 2 | 22.2 | |
| Negative | 150 | 86.2 | 4 | 2.7 | |
| Final pathologic examination | |||||
| Tumor size | |||||
| Mean (mm) | 10.5±12.1 | (0–60) | 29.4±11.9 | (15– 50) | <0.0001 |
| <20 mm | 130 | 76.0 | 2 | 1.5 | 0.0001 |
| ≥20 mm | 41 | 24.0 | 7 | 17.1 | |
| Not specified | 3 | ||||
| Deep stromal invasion | |||||
| Mean (mm) | 5.8±7.8 | (0–40) | 17.8±8.8 | (6–30) | <0.0001 |
| <10 mm | 111 | 74.0 | 2 | 1.8 | 0.001 |
| ≥10 mm | 39 | 26.0 | 6 | 15.4 | |
| Not specified | 24 | 1 | |||
| Lymphovascular space invasion | |||||
| Yes | 61 | 35.1 | 7 | 11.5 | 0.006 |
| No | 113 | 64.9 | 2 | 1.8 | |
| Vaginal invasion | |||||
| Yes | 11 | 6.4 | 6 | 54.5 | <0.0001 |
| No | 161 | 93.6 | 3 | 1.9 | |
| Not specified | 2 | ||||
| Positive margin | |||||
| Yes | 9 | 5.2 | 4 | 44.4 | <0.0001 |
| No | 163 | 94.8 | 5 | 3.1 | |
| Not specified | 2 | ||||
FIGO, International Federation of Gynecology and Obstetrics; SLN, sentinel lymph node.